Reactome | EYA3 [nucleoplasm]

EYA3 [nucleoplasm]

Stable Identifier

R-HSA-5683622

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Eyes absent homolog 3

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - ATM phosphorylates EYA1-4 (Homo sapiens)
        
        EYA1-4 [nucleoplasm] (Homo sapiens)
        
        EYA3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99504 EYA3

Gene Names

EYA3

Chain

chain:1-573

Reference Genes

BioGPS Gene:2140 EYA3

COSMIC (genes):EYA3 EYA3

CTD Gene:2140 EYA3

dbSNP Gene:2140 EYA3

ENSEMBL:ENSG00000158161 EYA3

HGNC:3521 EYA3

KEGG:hsa:2140 EYA3

Monarch:2140 EYA3

NCBI Gene:2140 EYA3

OMIM:601655 EYA3

UCSC:Q99504 EYA3

Reference Transcript

Other Identifiers

11743304_a_at

11745458_a_at

11746219_a_at

11749047_x_at

11759488_at

1552314_PM_a_at

1552314_a_at

1554844_PM_at

1554844_at

16684110

206379_PM_at

206379_at

2140

226170_PM_at

226170_at

2403298

2403336

2403337

2403338

2403339

2403340

2403341

2403342

2403344

2403345

2403347

2403348

2403349

2403350

2403351

2403352

2403353

2403354

2403355

2403356

2403357

2403358

2403359

2403361

2403364

2403371

2403372

2403381

2403382

2403383

3036620

36693_at

53802_at

7914153

A_23_P74737

A_24_P122658

A_24_P466374

GE60278

GE850242

GO:0003824

GO:0004721

GO:0004725

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0006281

GO:0006302

GO:0006325

GO:0006338

GO:0007275

GO:0007601

GO:0009653

GO:0010212

GO:0016787

GO:0030154

GO:0043226

GO:0045739

GO:0046872

GO:0048856

GO:0050877

GO:0140096

GO:0140793

GO:2001240

HMNXSV003003226

HMNXSV003007035

HMNXSV003056197

Hs.293850.0.A1_3p_at

Hs2.46925.1.S1_3p_s_at

Hs2.46925.3.S1_3p_at

ILMN_1720529

ILMN_1728353

ILMN_1790562

PH_hs_0024669

TC01002416.hg

Y10262_s_at

g4503620_3p_at

Participates

as a member of

EYA1-4 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-EYA3 [nucleoplasm]

Inferred To

EYA3 [nucleoplasm] (Bos taurus)

EYA3 [nucleoplasm] (Caenorhabditis elegans)

EYA3 [nucleoplasm] (Canis familiaris)

EYA3 [nucleoplasm] (Danio rerio)

EYA3 [nucleoplasm] (Drosophila melanogaster)

EYA3 [nucleoplasm] (Gallus gallus)

EYA3 [nucleoplasm] (Mus musculus)

EYA3 [nucleoplasm] (Rattus norvegicus)

EYA3 [nucleoplasm] (Sus scrofa)

EYA3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001981.2, NP_001269489.1, NP_001269490.1, NP_001269491.1

ENSEMBL

ENSP00000442558, ENSP00000405587, ENSP00000362978, ENSP00000362970, ENST00000373871, ENSG00000158161, ENST00000373863, ENST00000540618, ENST00000436342

OpenTargets

ENSG00000158161

GeneCards

EYA3

HPA

ENSG00000158161-EYA3

PRO

Q99504

Pharos - Targets

Q99504

GlyGen

Q99504

HMDB Protein

HMDBP08722

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3