Reactome | ATG7:ATG3:LC3 dissociates

ATG7:ATG3:LC3 dissociates

Stable Identifier

R-HSA-5683593

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ATG7 dissociates from the ATG3-LC3 conjugate (Tanida et al. 2012, Klionsky & Schulman 2014).

Literature References

PubMed ID	Title	Journal	Year
22170151	The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation Tanida, I, Komatsu, M, Yamasaki, M, Ueno, T	Autophagy	2012
11825910	Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p Tanida, I, Tanida-Miyake, E, Komatsu, M, Kominami, E, Ueno, T	J. Biol. Chem.	2002
24747438	Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3 Nath, S, Shteyn, V, Yamamoto, A, Melia, TJ, Dancourt, J, Bewersdorf, J, Nag, S, Puente, G, Antonny, B, Fong, WM	Nat. Cell Biol.	2014