Reactome | UIMC1 and FAM175A bind DNA DSBs

UIMC1 and FAM175A bind DNA DSBs

Stable Identifier

R-HSA-5683384

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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UIMC1 (RAP80) is recruited to DNA double-strand breaks (DSBs) through the interaction of its UIM (ubiquitin interaction motif) region with H2AFX (H2AX) ubiquitinated by RNF8 and RNF168 (Huen et al. 2007, Wang and Elledge 2007, Kolas et al. 2007, Mailand et al. 2007). A simultaneous interaction with FAM175A (Abraxas) through the AIR (Abraxas-interaction region) domain of UIMC1 facilitates UIMC1 binding to DNA DSBs. The interaction between UIMC1 and FAM175A and their loading to DNA DSBs is independent of BRCA1 (Wang et al. 2007, Wang and Elledge 2007).

Literature References

PubMed ID	Title	Journal	Year
18006705	Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase Kolas, NK, Chapman, JR, Nakada, S, Ylanko, J, Chahwan, R, Sweeney, FD, Panier, S, Mendez, M, Wildenhain, J, Thomson, TM, Pelletier, L, Jackson, SP, Durocher, D	Science	2007
18001825	RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly Huen, MS, Grant, R, Manke, I, Minn, K, Yu, X, Yaffe, MB, Chen, J	Cell	2007
18001824	RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins Mailand, N, Bekker-Jensen, S, Faustrup, H, Melander, F, Bartek, J, Lukas, C, Lukas, J	Cell	2007
18077395	Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage Wang, B, Elledge, SJ	Proc. Natl. Acad. Sci. U.S.A.	2007
17525340	Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response Wang, B, Matsuoka, S, Ballif, BA, Zhang, D, Smogorzewska, A, Gygi, SP, Elledge, SJ	Science	2007