UIMC1 and FAM175A bind DNA DSBs

Stable Identifier
R-HSA-5683384
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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UIMC1 (RAP80) is recruited to DNA double strand breaks (DSBs) through the interaction of its UIM (ubiquitin interaction motif) region with H2AFX (H2AX) ubiquitinated by RNF8 and RNF168 (Huen et al. 2007, Wang and Elledge 2007, Kolas et al. 2007, Mailand et al. 2007). A simultaneous interaction with FAM175A (Abraxas) through the AIR (Abraxas-interaction region) domain of UIMC1 facilitates UIMC1 binding to DNA DSBs. The interaction between UIMC1 and FAM175A and their loading to DNA DSBs is independent of BRCA1 (Wang et al. 2007, Wang and Elledge 2007).

Literature References
PubMed ID Title Journal Year
18001825 RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

Huen, MS, Grant, R, Manke, I, Minn, K, Yu, X, Yaffe, MB, Chen, J

Cell 2007
18006705 Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

Kolas, NK, Chapman, JR, Nakada, S, Ylanko, J, Chahwan, R, Sweeney, FD, Panier, S, Mendez, M, Wildenhain, J, Thomson, TM, Pelletier, L, Jackson, SP, Durocher, D

Science 2007
18001824 RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

Mailand, N, Bekker-Jensen, S, Faustrup, H, Melander, F, Bartek, J, Lukas, C, Lukas, J

Cell 2007
18077395 Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

Wang, B, Elledge, SJ

Proc. Natl. Acad. Sci. U.S.A. 2007
17525340 Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

Wang, B, Matsuoka, S, Ballif, BA, Zhang, D, Smogorzewska, A, Gygi, SP, Elledge, SJ

Science 2007
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