KDM4A,B bind H4K20Me2

Stable Identifier
R-HSA-5682992
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Histone demethylases KDM4A (JMJD2A) and KDM4B (JMJD2B) bind H4K20Me2 (Me2-K21-HIST1H4A) with a higher affinity than TP53BP1 (53BP1), thereby blocking TP53BP1 recruitment to DNA double strand breaks (DSBs). Demethylation of HIST1H4A (histone H4) by KDM4A or KDM4B is not involved in the inhibition of TP53BP1 binding (Mallette et al. 2012).

Literature References
PubMed ID Title Journal Year
22373579 RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Mallette, FA, Mattiroli, F, Cui, G, Young, LC, Hendzel, MJ, Mer, G, Sixma, TK, Richard, S

EMBO J. 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed