Reactome | LGI2 binds ADAM22,23

LGI2 binds ADAM22,23

Stable Identifier

R-HSA-5682769

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Leucine-rich glioma inactivated 2 (LGI2) like LIG1, is neuronally secreted and acts on ADAM (a-disintegrin-and-metalloproteinase) family of neuronal membrane proteins, which function in synapse remodelling. Based on the experiments performed in canine and rat brain it proves that LGI2 interacts with ADAM22 and ADAM23 following secretion. Truncation of Lgi2 prevents its secretion and ADAM interactions causing remitting focal-onset epilepsy in dogs between ages one and four months, which is equivalent to human two to eight years. It has been suggested that LGI2 participates in protecting the brain against seizures during the pruning phase of neurodevelopment (Seppala et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21829378	LGI2 truncation causes a remitting focal epilepsy in dogs Seppälä, EH, Jokinen, TS, Fukata, M, Fukata, Y, Webster, MT, Karlsson, EK, Kilpinen, SK, Steffen, F, Dietschi, E, Leeb, T, Eklund, R, Zhao, X, Rilstone, JJ, Lindblad-Toh, K, Minassian, BA, Lohi, H	PLoS Genet.	2011