Reactome | LGI4 binds ADAM22,23,11

LGI4 binds ADAM22,23,11

Stable Identifier

R-HSA-5682709

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Leucine-rich glioma inactivated 4 (LGI4) protein is another candidate ligand for ADAM22 receptor. Schwann cells secrete LGI4, which through binding to the axonal receptor ADAM22 drives axonal ensheathment and myelination in the peripheral nervous system (PNS) but not central nervous system. LGI4 secretion defect results in inability of Schwann cells to correctly myelinate peripheral nerves, resulting in peripheral nervous system hypomyelination and the murine claw-paw phenotype (Birmingham et al. 2006). LGI4 interacts with not only ADAM22 but also interacts moderately with ADAM11 and ADAM23 (Ozkaynak et al. 2010, Sagane et al. 2008, Nishino et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20220021	Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling Kegel, L, Abello, G, Sagane, K, van Berge, L, Ozkaynak, E, Meijer, D, Hamer, D, Jaegle, M, Bermingham, JR, Driegen, S	J. Neurosci.	2010
18974846	LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11 Sugimoto, H, Sagane, K, Ishihama, Y	Int. J. Biol. Sci.	2008