Reactome | HERC2 facilitates UBE2N:UBE2V2 binding to RNF8

HERC2 facilitates UBE2N:UBE2V2 binding to RNF8

Stable Identifier

R-HSA-5682629

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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HERC2 facilitates UBE2N:UBE2V2 binding to RNF8

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HERC2 facilitates binding of the E2 ubiquitin conjugase dimer UBE2N:UBE2V2 (UBC13:MMS2) to RNF8 at DNA double-strand breaks (DSBs) (Kolas et al. 2007, Bekker-Jensen et al. 2010, Campbell et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
20023648	HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes Lukas, J, Gromova, I, Rendtlew Danielsen, J, Bartek, J, Nerstedt, A, Lukas, C, Fugger, K, Bekker-Jensen, S, Mailand, N	Nat. Cell Biol.	2010
18006705	Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase Jackson, SP, Thomson, TM, Pelletier, L, Chapman, JR, Durocher, D, Panier, S, Mendez, M, Wildenhain, J, Nakada, S, Kolas, NK, Chahwan, R, Sweeney, FD, Ylanko, J	Science	2007
22589545	Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation Campbell, SJ, Neculai, D, Leung, CC, Glover, JN, Dhe-Paganon, S, Hodge, CD, Edwards, RA	J. Biol. Chem.	2012