Reactome | p-S406-FAM175A [nucleoplasm]

p-S406-FAM175A [nucleoplasm]

Stable Identifier

R-HSA-5682575

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S406-Abraxas, p-S406-ABRA1, p-S406-CCDC98

Locations in the PathwayBrowser for interactor UniProt:Q96RL1

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External Reference Information

External Reference

UniProt:Q6UWZ7 ABRAXAS1

Gene Names

FAM175A, ABRA1, CCDC98, UNQ496/PRO1013, ABRAXAS1

Chain

chain:1-409

Reference Genes

BioGPS Gene:84142 FAM175A

CTD Gene:84142 FAM175A

dbSNP Gene:84142 FAM175A

ENSEMBL:ENSG00000163322 FAM175A

HGNC:25829 FAM175A

KEGG Gene (Homo sapiens):84142 FAM175A

Monarch:84142 FAM175A

NCBI Gene:84142 FAM175A

OMIM:611143 FAM175A

UCSC:Q6UWZ7 FAM175A

Reference Transcript

Other Identifiers

0002370064

11729279_x_at

11729280_a_at

16977579

226521_s_at

233543_s_at

2776087

2776089

2776090

2776091

2776092

2776093

2776094

2776095

2776098

2776099

2776102

2776103

2776104

2776105

2776112

2776118

2776119

3126148

3126149

64716_at

8101489

84142

A_23_P253464

A_24_P311577

GE83329

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006259

GO:0006281

GO:0006302

GO:0006303

GO:0006325

GO:0006464

GO:0006950

GO:0006974

GO:0007010

GO:0007049

GO:0007059

GO:0007165

GO:0008017

GO:0008092

GO:0008150

GO:0008608

GO:0010212

GO:0016579

GO:0016604

GO:0022607

GO:0031593

GO:0032991

GO:0034641

GO:0043226

GO:0045739

GO:0051276

GO:0070531

GO:0070536

GO:0072425

GO:0090307

GO:0140014

HMNXSV003037891

Hs.3385.3.A1_3p_at

Hs.3385.4.S1_3p_a_at

ILMN_1748290

ILMN_1754344

ILMN_3237177

PH_hs_0016473

TC04001349.hg

Participates

as an output of

as a component of

as an input of

UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)

Inferred To

phospho-ABRAXAS1 [nucleoplasm] (Canis familiaris)

phospho-ABRAXAS1 [nucleoplasm] (Rattus norvegicus)

phospho-ABRAXAS1 [nucleoplasm] (Sus scrofa)

phospho-FAM175A [nucleoplasm] (Gallus gallus)

phospho-abraxas1 [nucleoplasm] (Danio rerio)

phospho-Abraxas1 [nucleoplasm] (Mus musculus)

Modified Residues

Name

O-phospho-L-serine at 406

Coordinate

406

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001332891.1, NP_620775.2

HPA

ENSG00000163322-ABRAXAS1

GeneCards

Q6UWZ7

Ensembl

ENSG00000163322, ENSP00000369857, ENST00000321945

PRO

Q6UWZ7

Orphanet

24528

PDB

4U4A, 4Y18, 4Y2G, 4JLU

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.818	15
UniProt:Q96RL1 UIMC1	1	UIMC1 [nucleoplasm] (R-HSA-5682574)	0.688	9
UniProt:P46736 BRCC3	2	BRCC3 [nucleoplasm] (R-HSA-5682577) BRCC3 [cytosol] (R-HSA-5691415)	0.656	4
UniProt:Q96RL1-1 UIMC1			0.656	4
UniProt:Q9NWV8 BABAM1	2	BABAM1 [nucleoplasm] (R-HSA-5682582) BABAM1 [cytosol] (R-HSA-5691418)	0.564	2

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