LC3 de-lipidation by ATG4

Stable Identifier
R-HSA-5682377
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LC3:PE can be cleaved by ATG4 to release free LC3 (Kirisako et al. 2000, Kabeya et al. 2004, Kumanomidou et al. 2006, Satoo et al. 2009). ATG4 activity can be regulated by reactive oxygen species (ROS) (Scherz-Shouval et al. 2007) possibily to control release of LC3 from closed autophagosomes.

Literature References
PubMed ID Title Journal Year
19322194 The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

Satoo, K, Noda, NN, Kumeta, H, Fujioka, Y, Mizushima, N, Ohsumi, Y, Inagaki, F

EMBO J. 2009
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of ATG4 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created