LC3 de-lipidation by ATG4

Stable Identifier
R-HSA-5682377
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, phagophore assembly site membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
LC3 de-lipidation by ATG4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
LC3:PE can be cleaved by ATG4 to release free LC3 (Kirisako et al. 2000, Kabeya et al. 2004, Kumanomidou et al. 2006, Satoo et al. 2009). ATG4 activity can be regulated by reactive oxygen species (ROS) (Scherz-Shouval et al. 2007) possibily to control release of LC3 from closed autophagosomes.
Literature References
PubMed ID Title Journal Year
19322194 The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy

Fujioka, Y, Inagaki, F, Ohsumi, Y, Mizushima, N, Satoo, K, Kumeta, H, Noda, NN

EMBO J. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of ATG4 [cytosol]

Physical Entity
ATG4 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
LC3 de-lipidation by ATG4 (Bos taurus)
LC3 de-lipidation by ATG4 (Caenorhabditis elegans)
LC3 de-lipidation by ATG4 (Canis familiaris)
LC3 de-lipidation by ATG4 (Danio rerio)
LC3 de-lipidation by ATG4 (Dictyostelium discoideum)
LC3 de-lipidation by ATG4 (Drosophila melanogaster)
LC3 de-lipidation by ATG4 (Gallus gallus)
LC3 de-lipidation by ATG4 (Mus musculus)
LC3 de-lipidation by ATG4 (Plasmodium falciparum)
LC3 de-lipidation by ATG4 (Rattus norvegicus)
LC3 de-lipidation by ATG4 (Sus scrofa)
Authored
Jupe, S  (2015-02-02)
Reviewed
Klionsky, DJ  (2015-09-03)
Tooze, SA  (2015-05-13)
Created
Jupe, S  (2015-03-06)
Cite Us!