PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer

Stable Identifier
R-HSA-5682101
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ATP-binding cassette sub-family A member 1 (ABCA1) is a key mediator of cholesterol and phospholipid efflux to apolipoprotein particles. This efflux activity is regulated by protein kinase A (PKA) site-specific phosphorylation of ABCA1 at Ser-1042 and Ser-2054, located in the nucleotide binding domains of ABCA1 (See et al. 2002).

Literature References
PubMed ID Title Journal Year
12196520 Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux

See, RH, Caday-Malcolm, RA, Singaraja, RR, Zhou, S, Silverston, A, Huber, MT, Moran, J, James, ER, Janoo, R, Savill, JM, Rigot, V, Zhang, LH, Wang, M, Chimini, G, Wellington, CL, Tafuri, SR, Hayden, MR

J. Biol. Chem. 2002
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Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PKA catalytic subunit [cytosol]
Physical Entity
Activity
Orthologous Events
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