Reactome | ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer

ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer

Stable Identifier

R-HSA-5682084

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer

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Palmitoylation of ATP-binding cassette sub-family A member 1 (ABCA1) at Cys 3, 23, 1110 and 1111 is essential for its proper trafficking from the ER membrane to the plasma membrane where it is essential for the transport of lipids. The probable palmitoyltransferase ZDHHC8 mediates the palmitoylation of ABCA1 (Singaraja et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19556522	Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function Vaid, K, El-Husseini, Ael D, Sanders, SS, Arstikaitis, P, Hayden, MR, Drisdel, RC, Kang, MH, Singaraja, RR, Berthiaume, L, Green, WN, Vilas, GL, Coutinho, J	Circ. Res.	2009