ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer

Stable Identifier
R-HSA-5682084
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Palmitoylation of ATP-binding cassette sub-family A member 1 (ABCA1) at Cys 3, 23, 1110 and 1111 is essential for its proper trafficking from the ER membrane to the plasma membrane where it is essential for the transport of lipids. The probable palmitoyltransferase ZDHHC8 mediates the palmitoylation of ABCA1 (Singaraja et al. 2009).

Literature References
PubMed ID Title Journal Year
19556522 Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function

Singaraja, RR, Kang, MH, Vaid, K, Sanders, SS, Vilas, GL, Arstikaitis, P, Coutinho, J, Drisdel, RC, El-Husseini, Ael D, Green, WN, Berthiaume, L, Hayden, MR

Circ. Res. 2009
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein-cysteine S-palmitoyltransferase activity of ZDHHC8 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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