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Shortened telomere:MRN [nucleoplasm]
Stable Identifier
R-HSA-5682022
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
KAT5 acetylates ATM at shortened telomeres (Homo sapiens)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN bound to shortened telomeres activates ATM (Homo sapiens)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN complex binds shortened telomeres (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17694070
MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control
Xiao, S
,
Wu, Y
,
Zhu, XD
Nat. Struct. Mol. Biol.
2007
Participants
components
MRN [nucleoplasm]
(Homo sapiens)
Shortened telomere [nucleoplasm]
Participates
as an output of
MRN complex binds shortened telomeres (Homo sapiens)
as an input of
MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)
as a component of
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Inferred To
Shortened telomere:MRN [nucleoplasm]
(Bos taurus)
Shortened telomere:MRN [nucleoplasm]
(Canis familiaris)
Shortened telomere:MRN [nucleoplasm]
(Dictyostelium discoideum)
Shortened telomere:MRN [nucleoplasm]
(Drosophila melanogaster)
Shortened telomere:MRN [nucleoplasm]
(Gallus gallus)
Shortened telomere:MRN [nucleoplasm]
(Mus musculus)
Shortened telomere:MRN [nucleoplasm]
(Rattus norvegicus)
Shortened telomere:MRN [nucleoplasm]
(Saccharomyces cerevisiae)
Shortened telomere:MRN [nucleoplasm]
(Schizosaccharomyces pombe)
Shortened telomere:MRN [nucleoplasm]
(Sus scrofa)
Cross References
ComplexPortal
CPX-4442
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