MRN complex binds shortened telomeres

Stable Identifier
R-HSA-5682020
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MRN complex binds shortened telomeres
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The MRN complex (MRE11:RAD50:NBS1 also known as MRE11A:RAD50:NBN) binds telomeric DNA, and MRN association with telomeric DNA is mutually exclusive with shelterin binding (Wu et al. 2007).
Literature References
PubMed ID Title Journal Year
17694070 MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

Xiao, S, Wu, Y, Zhu, XD

Nat. Struct. Mol. Biol. 2007
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Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2015-03-05)
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