ATG5 interacts with the small coiled-coil protein ATG16L1. The resulting ATG12-ATG5-ATG16L1 complex multimerizes through the oligomerization of ATG16L1 (Mizushima et al. 1999, 2003). The molecular weight of this multimeric complex suggests that it probably represents a tetramer of ATG12-ATG5-ATG16L1 (Kuma et al. 2002).
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