LC3 binds ATG7 dimer

Stable Identifier
R-HSA-5682011
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The exposed LC3 protein C-terminal glycine forms a thioester bond with Cys-572 of ATG7, the same residue that participates in Atg12-Atg5 conjugation (Ichimura et al. 2000, Tanida et al. 2001, 2012).
Literature References
PubMed ID Title Journal Year
22170151 The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation

Tanida, I, Komatsu, M, Yamasaki, M, Ueno, T

Autophagy 2012
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!