LC3 binds ATG7 dimer

Stable Identifier
R-HSA-5682011
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The exposed LC3 protein C-terminal glycine forms a thioester bond with Cys-572 of ATG7, the same residue that participates in Atg12-Atg5 conjugation (Ichimura et al. 2000, Tanida et al. 2001, 2012).

Literature References
PubMed ID Title Journal Year
22170151 The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation

Tanida, I, Yamasaki, M, Komatsu, M, Ueno, T

Autophagy 2012
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