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LC3 binds ATG7 dimer
Stable Identifier
R-HSA-5682011
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Autophagy (Homo sapiens)
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LC3 binds ATG7 dimer (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The exposed LC3 protein C-terminal glycine forms a thioester bond with Cys-572 of ATG7, the same residue that participates in Atg12-Atg5 conjugation (Ichimura et al. 2000, Tanida et al. 2001, 2012).
Literature References
PubMed ID
Title
Journal
Year
22170151
The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation
Tanida, I
,
Komatsu, M
,
Yamasaki, M
,
Ueno, T
Autophagy
2012
Participants
Input
ATG7 dimer [cytosol]
(Homo sapiens)
LC3 family [cytosol]
(Homo sapiens)
Output
CysO572-ATG7-LC3:ATG7 [cytosol]
(Homo sapiens)
Participates
as an event of
Macroautophagy (Homo sapiens)
Orthologous Events
LC3 binds ATG7 dimer (Bos taurus)
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LC3 binds ATG7 dimer (Drosophila melanogaster)
LC3 binds ATG7 dimer (Gallus gallus)
LC3 binds ATG7 dimer (Mus musculus)
LC3 binds ATG7 dimer (Plasmodium falciparum)
LC3 binds ATG7 dimer (Rattus norvegicus)
LC3 binds ATG7 dimer (Saccharomyces cerevisiae)
LC3 binds ATG7 dimer (Schizosaccharomyces pombe)
LC3 binds ATG7 dimer (Sus scrofa)
LC3 binds ATG7 dimer (Xenopus tropicalis)
Authored
Jupe, S (2015-02-02)
Reviewed
Klionsky, DJ (2015-09-03)
Tooze, SA (2015-05-13)
Created
Jupe, S (2015-03-04)
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