ATG10 transfers ATG12 from ATG7 to ATG10

Stable Identifier
R-HSA-5681999
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ATG10 transfers ATG12 from ATG7 to ATG10
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After activation, ATG12 is transferred to ATG10, which has a function that is analogous to an E2 enzyme (Shintani et al. 1999, Mizushima et al. 2002). ATG12 is transferred to the Cys-166 residue of ATG10 to form a thioester (Nemoto et al. 2003).
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Output
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Catalyst Activity

Atg12 transferase activity of ATG12:ATG7:CysO572-ATG7:ATG10 [cytosol]

Physical Entity
ATG12:ATG7:CysO572-ATG7:ATG10 [cytosol] (Homo sapiens)
Activity
Atg12 transferase activity (GO:0019777)
Inferred From
Atg10 transfers to Atg12 from Atg7 to Atg10 (Mus musculus)
Authored
Jupe, S  (2015-02-02)
Reviewed
Klionsky, DJ  (2015-09-03)
Tooze, SA  (2015-05-13)
Created
Jupe, S  (2015-03-04)
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