ATG10 transfers ATG12 from ATG7 to ATG10

Stable Identifier
R-HSA-5681999
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ATG10 transfers ATG12 from ATG7 to ATG10
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After activation, ATG12 is transferred to ATG10, which has a function that is analogous to an E2 enzyme (Shintani et al. 1999, Mizushima et al. 2002). ATG12 is transferred to the Cys-166 residue of ATG10 to form a thioester (Nemoto et al. 2003).

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
Atg12 transferase activity of ATG12:ATG7:CysO572-ATG7:ATG10 [cytosol]
Physical Entity
ATG12:ATG7:CysO572-ATG7:ATG10 [cytosol]
Activity
Atg12 transferase activity (0019777)
Inferred From
Atg10 transfers to Atg12 from Atg7 to Atg10 (Mus musculus)
Authored
Jupe, S  (2015-02-02)
Reviewed
Tooze, SA  (2015-05-13)
Klionsky, DJ  (2015-09-03)
Created
Jupe, S  (2015-03-04)