Reactome | LC3 is cleaved by ATG4

LC3 is cleaved by ATG4

Stable Identifier

R-HSA-5681987

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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LC3 family proteins are processed by members of the ATG4 family, which remove a C-terminal residue to create an exposed C-terminal glycine (Kirisako et al. 2000, Tanida et al. 2004, Kabeya et al. 2004, Li et al. 2011). Processed LC3 proteins are sometimes referred to as LC3-I.

Literature References

PubMed ID	Title	Journal	Year
21177865	Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates Li, M, Hou, Y, Wang, J, Chen, X, Shao, ZM, Yin, XM	J. Biol. Chem.	2011
15187094	HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates Tanida, I, Sou, YS, Ezaki, J, Minematsu-Ikeguchi, N, Ueno, T, Kominami, E	J. Biol. Chem.	2004