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ATG12 binds ATG7 dimer
Stable Identifier
R-HSA-5681980
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ATG12 binds ATG7 dimer (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ATG7 acts as an E1-like enzyme for ATG12. It binds to and activates ATG12, allow its transfer to the E2-like ATG10. The amino-acid sequence of ATG12 ends with a glycine residue and does not require protease activation. ATG12 is activated by forming a thioester bond between its C-terminal Gly-140 and Cys-572 of ATG7 (Tanida et al. 1999, 2001). ATG7 has been shown to function in the form of a homodimer (Komatsu et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
11096062
The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3
Tanida, I
,
Ueno, T
,
Tanida-Miyake, E
,
Kominami, E
J. Biol. Chem.
2001
Participants
Input
ATG12 [cytosol]
(Homo sapiens)
ATG7 dimer [cytosol]
(Homo sapiens)
Output
ATG12:ATG7 dimer [cytosol]
(Homo sapiens)
Participates
as an event of
Macroautophagy (Homo sapiens)
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Authored
Jupe, S (2015-02-02)
Reviewed
Klionsky, DJ (2015-09-03)
Tooze, SA (2015-05-13)
Created
Jupe, S (2015-03-04)
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