ATG12 binds ATG7 dimer

Stable Identifier
R-HSA-5681980
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ATG12 binds ATG7 dimer
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ATG7 acts as an E1-like enzyme for ATG12. It binds to and activates ATG12, allow its transfer to the E2-like ATG10. The amino-acid sequence of ATG12 ends with a glycine residue and does not require protease activation. ATG12 is activated by forming a thioester bond between its C-terminal Gly-140 and Cys-572 of ATG7 (Tanida et al. 1999, 2001). ATG7 has been shown to function in the form of a homodimer (Komatsu et al. 2001).
Literature References
PubMed ID Title Journal Year
11096062 The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3

Tanida, I, Ueno, T, Tanida-Miyake, E, Kominami, E

J. Biol. Chem. 2001
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Orthologous Events
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ATG12 binds ATG7 dimer (Drosophila melanogaster)
ATG12 binds ATG7 dimer (Gallus gallus)
ATG12 binds ATG7 dimer (Mus musculus)
ATG12 binds ATG7 dimer (Plasmodium falciparum)
ATG12 binds ATG7 dimer (Rattus norvegicus)
ATG12 binds ATG7 dimer (Saccharomyces cerevisiae)
ATG12 binds ATG7 dimer (Schizosaccharomyces pombe)
ATG12 binds ATG7 dimer (Sus scrofa)
ATG12 binds ATG7 dimer (Xenopus tropicalis)
Authored
Jupe, S  (2015-02-02)
Reviewed
Klionsky, DJ  (2015-09-03)
Tooze, SA  (2015-05-13)
Created
Jupe, S  (2015-03-04)
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