WIPI2 binds ATG12:ATG5:ATG16L

Stable Identifier
R-HSA-5679255
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, phagophore assembly site membrane
ReviewStatus
5/5
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WIPI2 binds ATG12:ATG5:ATG16L
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WIPI2 can bind ATG16L in the ATG12:ATG5:ATG16L complex (Dooley et al. 2014). Subsequently, LC3 is conjugated to PE. Other uncharacterised mechanisms are believed to lead to the recruitment of the ATG16L1 complex at the point of autophagosome nucleation (Fujita et al. 2008, Carlsson & Simonsen 2015).
Literature References
PubMed ID Title Journal Year
24954904 WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1

Tooze, SA, Polson, HE, Wilson, MI, Girardin, SE, Razi, M, Dooley, HC

Mol. Cell 2014
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Orthologous Events
WIPI2 binds ATG12:ATG5:ATG16L (Bos taurus)
WIPI2 binds ATG12:ATG5:ATG16L (Caenorhabditis elegans)
WIPI2 binds ATG12:ATG5:ATG16L (Canis familiaris)
WIPI2 binds ATG12:ATG5:ATG16L (Dictyostelium discoideum)
WIPI2 binds ATG12:ATG5:ATG16L (Drosophila melanogaster)
WIPI2 binds ATG12:ATG5:ATG16L (Gallus gallus)
WIPI2 binds ATG12:ATG5:ATG16L (Mus musculus)
WIPI2 binds ATG12:ATG5:ATG16L (Rattus norvegicus)
WIPI2 binds ATG12:ATG5:ATG16L (Sus scrofa)
Authored
Jupe, S  (2015-02-02)
Reviewed
Klionsky, DJ  (2015-09-03)
Tooze, SA  (2015-05-13)
Created
Jupe, S  (2015-03-03)
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