WIPI2 binds ATG12:ATG5:ATG16L

Stable Identifier
R-HSA-5679255
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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WIPI2 can bind ATG16L in the ATG12:ATG5:ATG16L complex (Dooley et al. 2014). Subsequently, LC3 is conjugated to PE. Other uncharacterised mechanisms are believed to lead to the recruitment of the ATG16L1 complex at the point of autophagosome nucleation (Fujita et al. 2008, Carlsson & Simonsen 2015).

Literature References
PubMed ID Title Journal Year
24954904 WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1

Dooley, HC, Razi, M, Polson, HE, Girardin, SE, Wilson, MI, Tooze, SA

Mol. Cell 2014
Participants
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Orthologous Events
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