ULK1 phosphorylates Beclin-1

Stable Identifier
R-HSA-5679205
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Following amino-acid starvation or mTOR inhibition, activated ULK1 phosphorylates BECN1 (Beclin-1) on Ser-15, thereby enhancing the activity of PIK3C3 (Vps34) in the Beclin-1 complex. This phosphorylation is required for full autophagic induction in mammals (Russell et al. 2013).

Literature References
PubMed ID Title Journal Year
23685627 ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Russell, RC, Tian, Y, Yuan, H, Park, HW, Chang, YY, Kim, J, Kim, H, Neufeld, TP, Dillin, A, Guan, KL

Nat. Cell Biol. 2013
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane]
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Activity
Orthologous Events
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Created