Reactome | ABCC2 I1173F [plasma membrane]

ABCC2 I1173F [plasma membrane]

Stable Identifier

R-HSA-5679030

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Multidrug resistance-associated protein 2, MRP2_HUMAN

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External Reference Information

External Reference

UniProt:Q92887 ABCC2

Gene Names

ABCC2, CMOAT, CMOAT1, CMRP, MRP2

Chain

chain:1-1545

Reference Genes

BioGPS Gene:1244 ABCC2

COSMIC (genes):ABCC2 ABCC2

CTD Gene:1244 ABCC2

dbSNP Gene:1244 ABCC2

ENSEMBL:ENSG00000023839 ABCC2

ENSEMBL_homo_sapiens_GENE:ENSG00000023839.12 ABCC2

HGNC:53 ABCC2

KEGG Gene (Homo sapiens):1244 ABCC2

Monarch:1244 ABCC2

NCBI Gene:1244 ABCC2

OMIM:601107 ABCC2

UCSC:Q92887 ABCC2

Reference Transcript

RefSeq:NM_000392.4 ABCC2

Other Identifiers

11730409_at

11759031_at

1244

16708192

206155_PM_at

206155_at

3260448

3260449

3260451

3260452

3260453

3260454

3260456

3260458

3260459

3260461

3260462

3260463

3260464

3260465

3260466

3260467

3260468

3260469

3260472

3260474

3260475

3260476

3260477

3260478

3260480

3260481

3260483

3260484

3260485

3260486

3260487

3260489

3260490

3260492

3260493

3260496

3260497

3260498

3260499

3260500

33721_at

67977_at

7929779

A_14_P113705

A_23_P158976

A_23_P44569

GE62639

GO:0000166

GO:0003013

GO:0003824

GO:0005215

GO:0005515

GO:0005524

GO:0005886

GO:0006805

GO:0006855

GO:0006869

GO:0008514

GO:0008559

GO:0009986

GO:0010629

GO:0015127

GO:0015431

GO:0015721

GO:0015723

GO:0016020

GO:0016324

GO:0016787

GO:0016887

GO:0022857

GO:0042167

GO:0042626

GO:0042910

GO:0043225

GO:0046581

GO:0046618

GO:0055085

GO:0070633

GO:0071716

GO:0098656

GO:0140359

GO:0140657

GO:0150104

GO:1990962

HMNXSV003017571

HMNXSV003037426

ILMN_1676278

PH_hs_0011436

TC10000715.hg

U49248_at

g4557480_3p_s_at

Participates

as a member of

ABCC2 mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

ABCC2 R768W [plasma membrane]

ABCC2 R1066* [plasma membrane]

ABCC2 R1150H [plasma membrane]

ABCC2 [plasma membrane]

Modified Residues

Name

L-isoleucine 1173 replaced with L-phenylalanine

Coordinate

1173

PsiMod

L-phenylalanine residue [MOD:00023]

A protein modification that effectively converts a source amino acid residue to L-phenylalanine.

L-isoleucine removal [MOD:01640]

A protein modification that effectively removes or replaces an L-isoleucine.

Disease

Name	Identifier	Synonyms
Dubin-Johnson syndrome	DOID:12308	chronic idiopathic jaundice, Dubin Johnson syndrome

Cross References

RefSeq

NP_000383.1

ZINC - World Drugs

MRP2_HUMAN

Guide to Pharmacology - Targets

780

OpenTargets

ENSG00000023839

ZINC - FDA approved

MRP2_HUMAN

ZINC - Substances

MRP2_HUMAN

ZINC target

Q92887

PRO

Q92887

PDB

8JXQ, 8JY4, 8JX7, 8IZR, 8JXU, 8JY5

IntEnz

7.6.2.2

HPA

ENSG00000023839-ABCC2

GeneCards

Q92887

Ensembl

ENSP00000497274, ENSG00000023839, ENST00000647814

Pharos - Targets

Q92887

Orphanet

15054

ZINC - Predictions - Purchasable

MRP2_HUMAN

HMDB Protein

HMDBP01658

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.508	3