IL17RA:IL17RE binds IL17C dimer

Stable Identifier
Reaction [omitted]
Homo sapiens
Interleukin-17 receptor A/E dimer binds IL17C dimer
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The Interleukin-17C (IL17C) dimers bind a heterodimeric receptor complex of Interleukin-17 receptor A (IL17RA) and IL17RE, which is expressed predominantly on epithelial cells . IL17C has an essential role in host mucosal defense against infection. It is an epithelial cell derived cytokine regulated by Toll-like receptor (TLR) agonists to promote host-defense responses (Ramirez-Carrozzi et al. 2011). This is a Black Box event because the order of receptor binding is unclear.

Literature References
PubMed ID Title Journal Year
21993849 IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

Song, X, Levin, SD, Shi, Y, Shi, P, Liu, Y, Zhu, S, Qian, Y

Nat. Immunol. 2011
21993848 IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

Lai, J, Ramirez-Carrozzi, V, Modrusan, Z, Pappu, R, Kim, J, Hackney, J, Jeet, S, Zhou, M, Lee, W, Balazs, M, Gonzalez, L, Ouyang, W, Xu, M, Lin, Z, Luis, E, de Voss, J, Singh, H, Caplazi, P, Sai, T, Lesch, J, Sambandam, A, Diehl, L

Nat. Immunol. 2011
23834281 IL-17C and its receptor IL-17RA/IL-17RE identify human oral epithelial cell as an inflammatory cell in recurrent aphthous ulcer

Konttinen, YT, Häyrinen-Immonen, R, Salem, A, Kaivosoja, E, Hietanen, J, Ainola, M, Kouri, VP, Al-Samadi, A, Barreto, G

J. Oral Pathol. Med. 2014
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