Reactome | BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2

BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2

Stable Identifier

R-HSA-5678315

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

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BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2

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Phosphorylation of AMBRA1 by ULK1 leads to the release of the Beclin-1 complex from the dynein motor complex, allowing it to relocalize and initiate autophagosome nucleation (Di Bartolomeo et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20921139	The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy Di Bartolomeo, S, Corazzari, M, Nazio, F, Oliverio, S, Lisi, G, Antonioli, M, Pagliarini, V, Matteoni, S, Fuoco, C, Giunta, L, D'Amelio, M, Nardacci, R, Romagnoli, A, Piacentini, M, Cecconi, F, Fimia, GM	J Cell Biol	2010