Beclin-1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2

Stable Identifier
R-HSA-5678315
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
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Beclin-1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2
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Phosphorylation of AMBRA1 by ULK1 leads to the release of the Beclin-1 complex from the dynein motor complex, allowing it to relocalize and initiate autophagosome nucleation (Di Bartolomeo et al. 2010).

Literature References
PubMed ID Title Journal Year
20921139 The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

Di Bartolomeo, S, Corazzari, M, Nazio, F, Oliverio, S, Lisi, G, Antonioli, M, Pagliarini, V, Matteoni, S, Fuoco, C, Giunta, L, D'Amelio, M, Nardacci, R, Romagnoli, A, Piacentini, M, Cecconi, F, Fimia, GM

J Cell Biol 2010
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Orthologous Events
Beclin-1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Bos taurus)
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Beclin-1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Gallus gallus)
Beclin-1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Mus musculus)
Beclin-1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Rattus norvegicus)
Beclin-1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Xenopus tropicalis)
Authored
Jupe, S  (2015-02-02)
Reviewed
Tooze, SA  (2015-05-13)
Klionsky, DJ  (2015-09-03)
Created
Jupe, S  (2015-02-23)