AMBRA1:DYNLL1,DYNLL2 binds Beclin-1 complex

Stable Identifier
R-HSA-5678313
Type
Reaction [binding]
Species
Homo sapiens
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AMBRA1 (activating molecule in Beclin 1-related autophagy 1) is a mammalian scaffold protein that interacts with BECN1 (Beclin-1) in the Beclin-1 complex, which consists of BECN1, PIK3C3 (VPS34), PIK3R4 (VPS15) and ATG14. AMBRA1 promotes the interaction of BECN1 with PIK3C3 (Fimia et al. 2007). AMBRA1 can simultaneously bind dynein and the Beclin-1 complex. This anchors Beclin-1 complexes to the cytoplasmic microtubule network (Di Bartolomeo et al. 2010, Fimia et al. 2011). Downregulation of AMBRA1 increased staurosporine- or etoposide-induced apoptosis (Gu et al. 2014).

Literature References
PubMed ID Title Journal Year
20921139 The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

Di Bartolomeo, S, Corazzari, M, Nazio, F, Oliverio, S, Lisi, G, Antonioli, M, Pagliarini, V, Matteoni, S, Fuoco, C, Giunta, L, D'Amelio, M, Nardacci, R, Romagnoli, A, Piacentini, M, Cecconi, F, Fimia, GM

J Cell Biol 2010
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