MRSBs reduce L-methyl-(R)-S-oxide to L-methionine

Stable Identifier
R-HSA-5676917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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MRSBs reduce L-methyl-(R)-S-oxide to L-methionine
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Methionine Sulfoxide Reductase B (MSRBs) are able to reduce methyl-(R)-S-oxide to methionine (Grimaud et al. 2001). They are specific for the reduction of protein-based methyl-(R)-S-oxide, reducing free methyl-(R)-S-oxide with very low efficiency (Lee et al. 2009). Mammals have at least 3 MSRB genes (Kryukov et al. 1999, Huang et al. 1999, Jung et al. 2002, Kim & Gladyshev 2004). They are ubiquitously expressed, no clear substrate specificities are known, all three contain a zinc atom and can use thioredoxin as an in vivo reducing agent (Kim & Gladyshev 2007).

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Catalyst Activity

peptide-methionine (R)-S-oxide reductase activity of MSRBs [cytosol]

Physical Entity
MSRBs [cytosol] (Homo sapiens)
Activity
peptide-methionine (R)-S-oxide reductase activity (GO:0033743)
Orthologous Events
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Bos taurus)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Canis familiaris)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Danio rerio)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Gallus gallus)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Mus musculus)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Rattus norvegicus)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Sus scrofa)
Authored
Jupe, S  (2015-01-05)
Reviewed
Meldal, BH  (2015-10-05)
Created
Jupe, S  (2015-02-20)
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