MRSBs reduce L-methyl-(R)-S-oxide to L-methionine

Stable Identifier
R-HSA-5676917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Methionine Sulfoxide Reductase B (MSRBs) are able to reduce methyl-(R)-S-oxide to methionine (Grimaud et al. 2001). They are specific for the reduction of protein-based methyl-(R)-S-oxide, reducing free methyl-(R)-S-oxide with very low efficiency (Lee et al. 2009). Mammals have at least 3 MSRB genes (Kryukov et al. 1999, Huang et al. 1999, Jung et al. 2002, Kim & Gladyshev 2004). They are ubiquitously expressed, no clear substrate specificities are known, all three contain a zinc atom and can use thioredoxin as an in vivo reducing agent (Kim & Gladyshev 2007).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peptide-methionine (R)-S-oxide reductase activity of MSRBs [cytosol]

Physical Entity
MSRBs [cytosol] (Homo sapiens)
Activity
peptide-methionine (R)-S-oxide reductase activity (GO:0033743)
Orthologous Events
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Bos taurus)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Caenorhabditis elegans)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Canis familiaris)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Danio rerio)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Gallus gallus)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Mus musculus)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Rattus norvegicus)
MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Sus scrofa)
Authored
Jupe, S  (2015-01-05)
Reviewed
Meldal, BH  (2015-10-05)
Created
Jupe, S  (2015-02-20)
Cite Us!