PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA

Stable Identifier
R-HSA-5676637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratases 1-4 (PTPLA, B, D1 and D2 respectively, aka HACD1-4) mediate the dehydration step in VLCFA synthesis. A very-long-chain (3R)-3-hydroxyacyl-CoA (VLC3HA-CoA) is dehydrated to a very-long-chain 2,3-trans-enoyl CoA (2,3-TE-CoA) (Ikeda et al. 2008).
Literature References
PubMed ID Title Journal Year
18554506 Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis

Ikeda, M, Kanao, Y, Yamanaka, M, Sakuraba, H, Igarashi, Y, Kihara, A, Mizutani, Y

FEBS Lett. 2008
Participants
Participates
Catalyst Activity

3-hydroxyacyl-CoA dehydratase activity of PTPLs [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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