PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA

Stable Identifier
R-HSA-5676637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratases 1-4 (PTPLA, B, D1 and D2 respectively, aka HACD1-4) mediate the dehydration step in VLCFA synthesis. A very-long-chain (3R)-3-hydroxyacyl-CoA (VLC3HA-CoA) is dehydrated to a very-long-chain 2,3-trans-enoyl CoA (2,3-TE-CoA) (Ikeda et al. 2008).

Literature References
PubMed ID Title Journal Year
18554506 Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis

Ikeda, M, Kanao, Y, Yamanaka, M, Sakuraba, H, Mizutani, Y, Igarashi, Y, Kihara, A

FEBS Lett. 2008
Participants
Participates
Catalyst Activity

3R-hydroxyacyl-CoA dehydratase activity of PTPLs [endoplasmic reticulum membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!