Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratases 1-4 (PTPLA, B, D1 and D2 respectively, aka HACD1-4) mediate the dehydration step in VLCFA synthesis. A very-long-chain (3R)-3-hydroxyacyl-CoA (VLC3HA-CoA) is dehydrated to a very-long-chain 2,3-trans-enoyl CoA (2,3-TE-CoA) (Ikeda et al. 2008).
Ikeda, M, Kanao, Y, Yamanaka, M, Sakuraba, H, Igarashi, Y, Kihara, A, Mizutani, Y
3R-hydroxyacyl-CoA dehydratase activity of PTPLs [endoplasmic reticulum membrane]
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