PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA

Stable Identifier
R-HSA-5676637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
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PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA
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Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratases 1-4 (PTPLA, B, D1 and D2 respectively, aka HACD1-4) mediate the dehydration step in VLCFA synthesis. A very-long-chain (3R)-3-hydroxyacyl-CoA (VLC3HA-CoA) is dehydrated to a very-long-chain 2,3-trans-enoyl CoA (2,3-TE-CoA) (Ikeda et al. 2008).

Literature References
PubMed ID Title Journal Year
18554506 Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis

Ikeda, M, Kanao, Y, Yamanaka, M, Sakuraba, H, Mizutani, Y, Igarashi, Y, Kihara, A

FEBS Lett. 2008
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Catalyst Activity

3R-hydroxyacyl-CoA dehydratase activity of PTPLs [endoplasmic reticulum membrane]

Physical Entity
PTPLs [endoplasmic reticulum membrane] (Homo sapiens)
Activity
3R-hydroxyacyl-CoA dehydratase activity (GO:0080023)
Orthologous Events
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Dictyostelium discoideum)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Gallus gallus)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Mus musculus)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Plasmodium falciparum)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Rattus norvegicus)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Saccharomyces cerevisiae)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Schizosaccharomyces pombe)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Sus scrofa)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Xenopus tropicalis)
Authored
Jassal, B  (2015-02-20)
Reviewed
D'Eustachio, P  (2015-02-22)
Created
Jassal, B  (2015-02-20)
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