Reactome | sBAFF trimer binds BAFFR

sBAFF trimer binds BAFFR

Stable Identifier

R-HSA-5676599

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

sTNFSF13B binds TNFRSF13C

ReviewStatus

5/5

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B cell activating factor of the TNF family (BAFF, also known as TNFSF13B) is a type II transmembrane protein that binds and predominantly activates its receptor BAFFR (TNFRSF13C) to transmit survival and growth signals to B cells (Li et al. 2008). BAFF is the most critical soluble factor for peripheral B-cell maturation and survival. BAFF is expressed by T cells, macrophages and dendritic cells, but not B cells. BAFF is primarily synthesised as membrane-bound but is proteolytically processed at furin consensus sequence to produce soluble protein. Processed, soluble BAFF adopts a usual trimeric form that appears to be the primary bioactive form of BAFF, but it is the only member of the family that can also further assemble as an ordered, capsid-like structure comprising twenty trimers. A trimeric BAFF ligand binds to three independent BAFFR (TNFRSF13C) receptor to initiate signalling (Liu et al. 2002, 2003, Mackay & Schneider 2009). BAFFR is predominantly expressed in B cells and contains a typical TNF receptor-associated factor (TRAF)-binding sites in their cytoplasmic domains which interacts with TRAF3 but not TRAF2 upon ligand interaction (Morrison et al. 2005). BAFF can also bind to other TNF superfamily (TNFSF) members, B cell maturation antigen (BCMA also known as TNFRSF17) and transmembrane activator and CAML interactor (TAC also known as TNFRSF13B) (Gross et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10359578	BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth Hofmann, K, Acha-Orbea, H, Lawton, P, Bixler, S, Tschopp, J, Browning, JL, Bodmer, JL, MacKay, F, Werner-Favre, C, Schneider, P, Zubler, RH, Ambrose, C, Holler, N, Romero, P, Valmori, D, Steiner, V	J. Exp. Med.	1999
12721620	Ligand-receptor binding revealed by the TNF family member TALL-1 Hong, X, Pan, CH, Shu, HB, Zhang, R, Martin, WE, Kappler, J, Zhang, G, Liu, Y, Dai, S, Murphy, RC, Jiang, L, Xu, L	Nature	2003
24432023	Non-Canonical NF-?B Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures Brink, R, Gardam, S	Front Immunol	2014
15368291	BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses Hancock, WW, Scott, ML, Wang, L, Han, R, Ye, Q, Davidson, A, Tao, R, Wells, AD	Eur. J. Immunol.	2004
11853672	Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands Opalka, N, Kappler, J, Zhang, G, Liu, Y, Shu, HB, Xu, L	Cell	2002