TRAFs bind RANK:RANKL

Stable Identifier
R-HSA-5676595
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Upon activation, RANK on osteoclasts sends signals into the cells by recruiting adapter proteins like tumor necrosis factor receptor-associated factors (TRAFs) and mediates activation of noncanonical NF-kB signalling pathways (Novack et al. 2003, Chaisson ML et al. 2004, Vaira et al. 2007). RANK interacts with TRAFs 1, 2, 3, 5, and 6 however, only TRAF2, TRAF5, and TRAF6 are functionally competent to activate signaling pathways (Kanazawa & Kudi 2004, Galibert et al. 1998, Darnay et al.1999, Darnay et al. 2000).

Literature References
PubMed ID Title Journal Year
15824857 TRAF2 is essential for TNF-alpha-induced osteoclastogenesis

Kanazawa, K, Kudo, A

J. Bone Miner. Res. 2005
9852070 The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily

Galibert, L, Tometsko, ME, Anderson, DM, Cosman, D, Dougall, WC

J. Biol. Chem. 1998
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