Upon activation, RANK on osteoclasts sends signals into the cells by recruiting adapter proteins like tumor necrosis factor receptor-associated factors (TRAFs) and mediates activation of noncanonical NF-kB signalling pathways (Novack et al. 2003, Chaisson ML et al. 2004, Vaira et al. 2007). RANK interacts with TRAFs 1, 2, 3, 5, and 6 however, only TRAF2, TRAF5, and TRAF6 are functionally competent to activate signaling pathways (Kanazawa & Kudi 2004, Galibert et al. 1998, Darnay et al.1999, Darnay et al. 2000).