2xRANK binds RANKL,sRANKL trimer:RANK

Stable Identifier
R-HSA-5676592
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The binding of RANKL trimer to RANK causes the trimerization of the receptor, which activates the signalling pathway and results in osteogenesis from progenitor cells and the activation of mature osteoclasts (Liu et al. 2010)

Literature References
PubMed ID Title Journal Year
9367155 A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

Anderson, DM, Maraskovsky, E, Billingsley, WL, Dougall, WC, Tometsko, ME, Roux, ER, Teepe, MC, DuBose, RF, Cosman, D, Galibert, L

Nature 1997
20483727 Structural and functional insights of RANKL-RANK interaction and signaling

Liu, C, Walter, TS, Huang, P, Zhang, S, Zhu, X, Wu, Y, Wedderburn, LR, Tang, P, Owens, RJ, Stuart, DI, Ren, J, Gao, B

J. Immunol. 2010
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