Reactome | RANKL,sRANKL trimer binds RANK

RANKL,sRANKL trimer binds RANK

Stable Identifier

R-HSA-5676589

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

TNFSF11,sTNFSF11 trimer binds TNFRSF11A

ReviewStatus

5/5

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Receptor activator of the NF-kB (RANK also known as TNFRSF11A) is a type I transmembrane protein expressed on osteoclast precursors, dendritic cells and activated B cells, and in general RANK signalling promotes cell survival and differentiation. RANK and its ligand RANKL (TNFSF11) are key regulators of bone remodeling, and they are essential for the development and activation of osteoclasts (Nakagawa et al. 1998). RANK/RANKL interaction also regulates important immune functions, such as dendritic cell survival and lymphoid organogenesis (Sun 2011, Theill et al. 2002). RANKL (also known as TNFSF11) is a type II transmembrane protein, primarily expressed on the surface of activated T-cells, bone marrow stromal cells, and osteoblasts. Soluble form of RANKL (sRANKL) that arise from either proteolytic cleavage or alternative splicing have also been observed. Both the membrane bound and soluble forms of RANKL are assembled into functional homotrimers like other members of the TNFSF (Liu et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20483727	Structural and functional insights of RANKL-RANK interaction and signaling Liu, C, Walter, TS, Huang, P, Zhang, S, Zhu, X, Wu, Y, Wedderburn, LR, Tang, P, Owens, RJ, Stuart, DI, Ren, J, Gao, B	J. Immunol.	2010
9367155	A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function Anderson, DM, Maraskovsky, E, Billingsley, WL, Dougall, WC, Tometsko, ME, Roux, ER, Teepe, MC, DuBose, RF, Cosman, D, Galibert, L	Nature	1997