RANKL,sRANKL trimer binds RANK

Stable Identifier
Reaction [binding]
Homo sapiens
TNFSF11,sTNFSF11 trimer binds TNFRSF11A
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Receptor activator of the NF-kB (RANK also known as TNFRSF11A) is a type I transmembrane protein expressed on osteoclast precursors, dendritic cells and activated B cells, and in general RANK signalling promotes cell survival and differentiation. RANK and its ligand RANKL (TNFSF11) are key regulators of bone remodeling, and they are essential for the development and activation of osteoclasts (Nakagawa et al. 1998). RANK/RANKL interaction also regulates important immune functions, such as dendritic cell survival and lymphoid organogenesis (Sun 2011, Theill et al. 2002). RANKL (also known as TNFSF11) is a type II transmembrane protein, primarily expressed on the surface of activated T-cells, bone marrow stromal cells, and osteoblasts. Soluble form of RANKL (sRANKL) that arise from either proteolytic cleavage or alternative splicing have also been observed. Both the membrane bound and soluble forms of RANKL are assembled into functional homotrimers like other members of the TNFSF (Liu et al. 2010).
Literature References
PubMed ID Title Journal Year
20483727 Structural and functional insights of RANKL-RANK interaction and signaling

Ren, J, Wu, Y, Walter, TS, Huang, P, Stuart, DI, Liu, C, Gao, B, Zhang, S, Owens, RJ, Wedderburn, LR, Zhu, X, Tang, P

J. Immunol. 2010
9367155 A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

Anderson, DM, DuBose, RF, Tometsko, ME, Billingsley, WL, Roux, ER, Maraskovsky, E, Galibert, L, Teepe, MC, Cosman, D, Dougall, WC

Nature 1997
Orthologous Events
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