Reactome | sAPRIL [extracellular region]

sAPRIL [extracellular region]

Stable Identifier

R-HSA-5676560

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

sTNFSF13, Tumor necrosis factor ligand superfamily member 13, TNF13_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - TNFs bind their physiological receptors (Homo sapiens)
      - sBAFF,sAPRIL binds TACI,BCMA (Homo sapiens)
        
        sBAFF,sAPRIL trimers [extracellular region] (Homo sapiens)
        
        sAPRIL trimer [extracellular region] (Homo sapiens)
        
        sAPRIL [extracellular region] (Homo sapiens)
        
        sBAFF,sAPRIL:3xTAC1,BCMA [plasma membrane] (Homo sapiens)
        
        sBAFF,sAPRIL trimers [extracellular region] (Homo sapiens)
        
        sAPRIL trimer [extracellular region] (Homo sapiens)
        
        sAPRIL [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75888 TNFSF13

Gene Names

TNFSF13, APRIL, TALL2, ZTNF2, UNQ383/PRO715

Chain

propeptide:1-104, chain:105-250

Reference Genes

BioGPS Gene:8741 TNFSF13

COSMIC (genes):TNFSF13 TNFSF13

CTD Gene:8741 TNFSF13

dbSNP Gene:8741 TNFSF13

ENSEMBL:ENSG00000161955 TNFSF13

ENSEMBL_homo_sapiens_GENE:ENSG00000161955.17 TNFSF13

HGNC:11928 TNFSF13

KEGG Gene (Homo sapiens):8741 TNFSF13

Monarch:8741 TNFSF13

NCBI Gene:8741 TNFSF13

OMIM:604472 TNFSF13

UCSC:O75888 TNFSF13

Reference Transcript

Other Identifiers

11730090_a_at

11753321_a_at

209499_PM_x_at

209499_x_at

209500_PM_x_at

209500_x_at

210314_PM_x_at

210314_x_at

211495_PM_x_at

211495_x_at

35287_at

3708778

3708779

3708780

3708781

3708782

3708783

3708785

3708788

3708789

3708790

3708791

3708792

3708793

3708794

3708795

3708796

3708797

3708799

3708800

8741

GE54821

GO:0002376

GO:0005102

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006310

GO:0006955

GO:0007154

GO:0007165

GO:0008284

GO:0016020

GO:0023052

GO:0043226

GO:0048018

GO:0048298

GO:0048856

GO:0070062

GO:0098772

HMNXSV003033399

Hs.54673.2.S1_3p_x_at

ILMN_1784264

ILMN_2399190

PH_hs_0003589

PH_hs_0031241

TC17002865.hg

g7328553_3p_a_at

g7328555_3p_a_at

Participates

as a component of

sAPRIL trimer [extracellular region] (Homo sapiens)

Other forms of this molecule

p-T243-TNFSF13 [cytosol]

p-T243-TNFSF13 [nucleoplasm]

Inferred To

april [extracellular region] (Danio rerio)

TNFSF13 [extracellular region] (Bos taurus)

TNFSF13 [extracellular region] (Canis familiaris)

TNFSF13 [extracellular region] (Sus scrofa)

Tnfsf13 [extracellular region] (Mus musculus)

Tnfsf13 [extracellular region] (Rattus norvegicus)

egr [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_001185552.1, NP_742085.1, NP_001185553.1, NP_742084.1, NP_003799.1

OpenTargets

ENSG00000161955

GeneCards

O75888

HPA

ENSG00000161955-TNFSF13

Ensembl

ENSP00000379794, ENSP00000343505, ENST00000349228, ENSP00000486052, ENST00000396542, ENST00000625791, ENST00000396545, ENSP00000314455, ENSP00000379792, ENST00000338784, ENSG00000161955

PRO

O75888

Pharos - Targets

O75888

Orphanet

25961

PDB

4ZCH