Reactome | sTNFSF11 [extracellular region]

sTNFSF11 [extracellular region]

Stable Identifier

R-HSA-5676547

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Tumor necrosis factor ligand superfamily member 11, TNF11_HUMAN, soluble RINKL, sRANKL

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
    - Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
      - 2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
        
        RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
      - RANKL,sRANKL trimer binds RANK (Homo sapiens)
        
        RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
      - TRAFs bind RANK:RANKL (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
    - TNFs bind their physiological receptors (Homo sapiens)
      - TNFSF11 binds TNFRSF11A, B (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
        
        TNFSF11,sTNFSF11 trimer:3xTNFRSF11B [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
        
        sRANKL trimer [extracellular region] (Homo sapiens)
        
        sTNFSF11 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14788 TNFSF11

Gene Names

TNFSF11, OPGL, RANKL, TRANCE

Chain

chain:1-317, chain:140-317

Reference Genes

BioGPS Gene:8600 TNFSF11

COSMIC (genes):TNFSF11 TNFSF11

CTD Gene:8600 TNFSF11

dbSNP Gene:8600 TNFSF11

ENSEMBL:ENSG00000120659 TNFSF11

HGNC:11926 TNFSF11

KEGG:hsa:8600 TNFSF11

Monarch:8600 TNFSF11

NCBI Gene:8600 TNFSF11

OMIM:602642 TNFSF11

UCSC:O14788 TNFSF11

Reference Transcript

Participates

as a component of

sRANKL trimer [extracellular region] (Homo sapiens)

Other forms of this molecule

TNFSF11 [plasma membrane]

Inferred To

Tnfsf11 [extracellular region] (Mus musculus)

Tnfsf11 [extracellular region] (Rattus norvegicus)

tnfsf10l [extracellular region] (Danio rerio)

tnfsf10l3 [extracellular region] (Danio rerio)

TNFSF11 [extracellular region] (Bos taurus)

TNFSF11 [extracellular region] (Canis familiaris)

TNFSF11 [extracellular region] (Gallus gallus)

TNFSF11 [extracellular region] (Sus scrofa)

tnfsf11 [extracellular region] (Xenopus tropicalis)

Homologues of sTNFSF11 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_003692.1, XP_047286663.1, XP_054231051.1, XP_016876292.1, NP_143026.1, XP_011533582.1, XP_054231053.1, XP_054231052.1

OpenTargets

ENSG00000120659

ENSEMBL

ENST00000358545, ENSP00000381775, ENSG00000120659, ENSP00000351347, ENST00000398795

HPA

ENSG00000120659-TNFSF11

GeneCards

TNFSF11

PRO

O14788

Pharos - Targets

O14788

Orphanet

TNFSF11

GlyGen

O14788

PDB

5BNQ, 3URF

HMDB Protein

HMDBP02409

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6Q6 TNFRSF11A	1	TNFRSF11A [plasma membrane] (R-HSA-5668756)	0.623	2
UniProt:O00300 TNFRSF11B	1	TNFRSF11B [plasma membrane] (R-HSA-5672848)	0.618	3
UniProt:P03886 MT-ND1	1	MT-ND1 [mitochondrial inner membrane] (R-HSA-60551)	0.527	2
UniProt:Q9UBS3 DNAJB9	1	DNAJB9 [endoplasmic reticulum membrane] (R-HSA-381010)	0.527	2

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