Reactome | ULK1 phosphorylates ATG13 and RB1CC1

ULK1 phosphorylates ATG13 and RB1CC1

Stable Identifier

R-HSA-5675868

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ULK1 (and ULK2) can phosphorylate both ATG13 and RB1CC1 (Hosakawa et al. 2009, Jung et al. 2009). Similarly Drosophila Atg1, the orthologue of ULK1, phosphorylates Drosophila Atg13 (Chang & Neufeld 2009). This phosphorylation is believed to be activating, opposing the inactivating phosphorylation of ATG13 by mTORC1 (Kamada et al. 2000, Hosakawa et al. 2009,Chang & Neufeld 2009, Jung et al. 2009) under conditions of nutrient sufficiency.

Literature References

PubMed ID	Title	Journal	Year
19211835	Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy Hosokawa, N, Hara, T, Kaizuka, T, Kishi, C, Takamura, A, Miura, Y, Iemura, S, Natsume, T, Takehana, K, Yamada, N, Guan, JL, Oshiro, N, Mizushima, N	Mol. Biol. Cell	2009