ULK1 phosphorylates ATG13 and RB1CC1

Stable Identifier
R-HSA-5675868
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ULK1 (and ULK2) can phosphorylate both ATG13 and RB1CC1 (Hosakawa et al. 2009, Jung et al. 2009). Similarly Drosophila Atg1, the orthologue of ULK1, phosphorylates Drosophila Atg13 (Chang & Neufeld 2009). This phosphorylation is believed to be activating, opposing the inactivating phosphorylation of ATG13 by mTORC1 (Kamada et al. 2000, Hosakawa et al. 2009,Chang & Neufeld 2009, Jung et al. 2009) under conditions of nutrient sufficiency.

Literature References
PubMed ID Title Journal Year
19211835 Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

Hosokawa, N, Hara, T, Kaizuka, T, Kishi, C, Takamura, A, Miura, Y, Iemura, S, Natsume, T, Takehana, K, Yamada, N, Guan, JL, Oshiro, N, Mizushima, N

Mol. Biol. Cell 2009
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hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol]
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Activity
Orthologous Events
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