Regulation of necroptotic cell death

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

A regulated balance between cell survival and cell death is essential for normal development and homeostasis of multicellular organisms. Defects in control of this balance may contribute to autoimmune disease, neurodegeneration and cancer.

Literature References
PubMed ID Title Journal Year
18621737 c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

Varfolomeev, E, Goncharov, T, Fedorova, AV, Dynek, JN, Zobel, K, Deshayes, K, Fairbrother, WJ, Vucic, D

J. Biol. Chem. 2008
20218968 c-FLIP is involved in erythropoietin-mediated protection of erythroid-differentiated cells from TNF-alpha-induced apoptosis

Vittori, D, Vota, D, Callero, M, Chamorro, ME, Nesse, A

Cell Biol. Int. 2010
12110583 c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

Chang, DW, Xing, Z, Pan, Y, Algeciras-Schimnich, A, Barnhart, BC, Yaish-Ohad, S, Peter, ME, Yang, X

EMBO J. 2002
15701649 c-FLIPR, a new regulator of death receptor-induced apoptosis

Golks, A, Brenner, D, Fritsch, C, Krammer, PH, Lavrik, IN

J. Biol. Chem. 2005
21737330 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Feoktistova, M, Geserick, P, Kellert, B, Dimitrova, DP, Langlais, C, Hupe, M, Cain, K, MacFarlane, M, H├Ącker, G, Leverkus, M

Mol. Cell 2011
18570872 cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

Bertrand, MJ, Milutinovic, S, Dickson, KM, Ho, WC, Boudreault, A, Durkin, J, Gillard, JW, Jaquith, JB, Morris, SJ, Barker, PA

Mol. Cell 2008
Participant Of
Event Information
Orthologous Events