Reactome | PEA15 [cytosol]

PEA15 [cytosol]

Stable Identifier

R-HSA-5675204

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:P28482%20MAPK1

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External Reference Information

External Reference

UniProt:Q15121 PEA15

Gene Names

PEA15

Chain

chain:1-130

Reference Genes

BioGPS Gene:8682 PEA15

COSMIC (genes):PEA15 PEA15

CTD Gene:8682 PEA15

dbSNP Gene:8682 PEA15

ENSEMBL:ENSG00000162734 PEA15

ENSEMBL_homo_sapiens_GENE:ENSG00000162734.13 PEA15

HGNC:8822 PEA15

KEGG Gene (Homo sapiens):8682 PEA15

Monarch:8682 PEA15

NCBI Gene:8682 PEA15

OMIM:603434 PEA15

UCSC:Q15121 PEA15

Reference Transcript

Other Identifiers

11756577_a_at

11757843_s_at

16672583

200787_PM_s_at

200787_s_at

200788_PM_s_at

200788_s_at

2363015

2363043

2363044

2363045

2363046

2363047

2363048

2363049

2363050

2363051

2363052

2363053

2363054

2363055

2363063

2363064

2363065

32260_at

7906564

8682

A_24_P250964

A_24_P410952

A_33_P3220827

GE79949

GO:0000165

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005875

GO:0006915

GO:0008643

GO:0012501

GO:0023052

GO:0042981

GO:0043226

GO:0043231

GO:0046325

GO:0055085

GO:1902042

GO:1902043

HMNXSV003047616

ILMN_1771376

PH_hs_0011496

TC01001364.hg

X86809_at

g12803230_3p_s_at

g4505704_3p_s_at

Participates

as an input of

PEA15 binds MAPK monomers and dimers (Homo sapiens)

as a component of

p-T,Y MAPK monomers and dimers:PEA15 [cytosol] (Homo sapiens)

Inferred To

pea15 [cytosol] (Xenopus tropicalis)

LOC107049501 [cytosol] (Gallus gallus)

Pea15 [cytosol] (Mus musculus)

Pea15 [cytosol] (Rattus norvegicus)

PEA15 [cytosol] (Bos taurus)

PEA15 [cytosol] (Canis familiaris)

PEA15 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001284507.1, NP_001284505.1, NP_001284506.1, XP_006711662.1, NP_003759.1

OpenTargets

ENSG00000162734

GeneCards

Q15121

HPA

ENSG00000162734-PEA15

Ensembl

ENSP00000353660, ENST00000360472, ENST00000368076, ENSP00000357055, ENSG00000162734

PRO

Q15121

Pharos - Targets

Q15121

HMDB Protein

HMDBP07939

PDB

6P6C, 4IZ5, 6P6B, 4IZA

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.675	4
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.666	4
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2

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