Reactome | MAP2Ks phosphorylate MAPK at the Golgi membrane

MAP2Ks phosphorylate MAPK at the Golgi membrane

Stable Identifier

R-HSA-5674373

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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MAP2Ks phosphorylate MAPK at the Golgi membrane

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Activated MAP2Ks in complex with IL17RD phosphorylate MAPKs at the Golgi membrane. IL17RD prevents the dissociation of phosphorylated MAPK from the complex at the Golgi as assessed by coimmunoprecipitation, preventing MAPK nuclear translocation and activation of nuclear targets (Torii et al, 2004; reviewed in Philips, 2004; Brown and Sacks, 2009).

Literature References

PubMed ID	Title	Journal	Year
19091303	Protein scaffolds in MAP kinase signalling Brown, MD, Sacks, DB	Cell. Signal.	2009
15260967	Sef: a MEK/ERK catcher on the Golgi Philips, MR	Mol. Cell	2004
15239952	Sef is a spatial regulator for Ras/MAP kinase signaling Maekawa, M, Kusakabe, M, Yamamoto, T, Nishida, E, Torii, S	Dev Cell	2004