Activated MAP2Ks in complex with IL17RD phosphorylate MAPKs at the Golgi membrane. IL17RD prevents the dissociation of phosphorylated MAPK from the complex at the Golgi as assessed by coimmunoprecipitation, preventing MAPK nuclear translocation and activation of nuclear targets (Torii et al, 2004; reviewed in Philips, 2004; Brown and Sacks, 2009).
Brown, MD, Sacks, DB
Philips, MR
Maekawa, M, Kusakabe, M, Yamamoto, T, Nishida, E, Torii, S
protein serine/threonine/tyrosine kinase activity of IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane]
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