Reactome | PAQR3 binds inactive RAFs

PAQR3 binds inactive RAFs

Stable Identifier

R-HSA-5674140

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

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PAQR3, also known as RKTG (Raf kinase trapping to Golgi) is a multi-pass transmembrane protein that binds to RAF1 and BRAF and sequesters them in the Golgi. This inhibits the interaction of RAF with activated RAS and the plasma membrane and inhibits RAF signaling (Feng et al, 2007; Fan et al, 2008; Luo et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
17724343	Spatial regulation of Raf kinase signaling by RKTG Feng, L, Xie, X, Ding, Q, Luo, X, He, J, Fan, F, Liu, W, Wang, Z, Chen, Y	Proc. Natl. Acad. Sci. U.S.A.	2007
18515281	RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells Fan, F, Feng, L, He, J, Wang, X, Jiang, X, Zhang, Y, Wang, Z, Chen, Y	Carcinogenesis	2008
18547165	Characterization of the topology and functional domains of RKTG Luo, X, Feng, L, Jiang, X, Xiao, F, Wang, Z, Feng, GS, Chen, Y	Biochem. J.	2008