PAQR3, also known as RKTG (Raf kinase trapping to Golgi) is a multi-pass transmembrane protein that binds to RAF1 and BRAF and sequesters them in the Golgi. This inhibits the interaction of RAF with activated RAS and the plasma membrane and inhibits RAF signaling (Feng et al, 2007; Fan et al, 2008; Luo et al, 2008).
Feng, L, Xie, X, Ding, Q, Luo, X, He, J, Fan, F, Liu, W, Wang, Z, Chen, Y
Fan, F, Feng, L, He, J, Wang, X, Jiang, X, Zhang, Y, Wang, Z, Chen, Y
Luo, X, Feng, L, Jiang, X, Xiao, F, Wang, Z, Feng, GS, Chen, Y
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