PAQR3 binds inactive RAFs

Stable Identifier
R-HSA-5674140
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PAQR3, also known as RKTG (Raf kinase trapping to Golgi) is a multi-pass transmembrane protein that binds to RAF1 and BRAF and sequesters them in the Golgi. This inhibits the interaction of RAF with activated RAS and the plasma membrane and inhibits RAF signaling (Feng et al, 2007; Fan et al, 2008; Luo et al, 2008).

Literature References
PubMed ID Title Journal Year
17724343 Spatial regulation of Raf kinase signaling by RKTG

Feng, L, Xie, X, Ding, Q, Luo, X, He, J, Fan, F, Liu, W, Wang, Z, Chen, Y

Proc. Natl. Acad. Sci. U.S.A. 2007
18515281 RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells

Fan, F, Feng, L, He, J, Wang, X, Jiang, X, Zhang, Y, Wang, Z, Chen, Y

Carcinogenesis 2008
18547165 Characterization of the topology and functional domains of RKTG

Luo, X, Feng, L, Jiang, X, Xiao, F, Wang, Z, Feng, GS, Chen, Y

Biochem. J. 2008
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