WDR83:LAMTOR2:LAMTOR3 binds MAPK components

Stable Identifier
Reaction [binding]
Homo sapiens
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LAMTOR3 (also known as MEK partner 1, MP1) exists in an obligatory complex with LAMTOR2 (p14) at the endosomal membrane where they act as a scaffold and promote MAPK activation (Schaeffer et al, 1998; Teis et al, 2002; Teis et al, 2006; Sharma et al, 2005). The LAMTOR2/LAMTOR3 complex may also be part of a larger molecular weight complex at the endosome that includes the MAPK organizer protein MORG1 (Vomastek et al, 2004; Sharma et al, 2005; reviewed in Matallanas et al, 2011).
Literature References
PubMed ID Title Journal Year
12479806 Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

Teis, D, Huber, LA, Wunderlich, W

Dev. Cell 2002
15547943 MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling

Sharma, C, Eblen, ST, Weber, MJ, Catling, AD, Tarcsafalvi, A, Vomastek, T, Schaeffer, HJ

J. Cell. Biochem. 2005
17178906 p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis

Teis, D, Kurzbauer, R, Villunger, A, de Araujo, ME, Geley, S, Erlacher, M, Offterdinger, M, Huber, LA, Taub, N, Hess, MW, Klein, C, Hilber, D, Bohn, G

J. Cell Biol. 2006
9733512 MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

Eblen, ST, Weber, MJ, Collier, LS, Catling, AD, Schaeffer, HJ, Krauss, A

Science 1998
15118098 Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

Weber, MJ, Tarcsafalvi, A, Vomastek, T, Schaeffer, HJ, Bissonette, EA, Smolkin, ME

Proc. Natl. Acad. Sci. U.S.A. 2004
21779496 Raf family kinases: old dogs have learned new tricks

Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A

Genes Cancer 2011
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