Reactome | WDR83:LAMTOR2:LAMTOR3 binds MAPK components

WDR83:LAMTOR2:LAMTOR3 binds MAPK components

Stable Identifier

R-HSA-5674132

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane

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WDR83:LAMTOR2:LAMTOR3 binds MAPK components

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LAMTOR3 (also known as MEK partner 1, MP1) exists in an obligatory complex with LAMTOR2 (p14) at the endosomal membrane where they act as a scaffold and promote MAPK activation (Schaeffer et al, 1998; Teis et al, 2002; Teis et al, 2006; Sharma et al, 2005). The LAMTOR2/LAMTOR3 complex may also be part of a larger molecular weight complex at the endosome that includes the MAPK organizer protein MORG1 (Vomastek et al, 2004; Sharma et al, 2005; reviewed in Matallanas et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
15547943	MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling Sharma, C, Vomastek, T, Tarcsafalvi, A, Catling, AD, Schaeffer, HJ, Eblen, ST, Weber, MJ	J. Cell. Biochem.	2005
12479806	Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction Teis, D, Wunderlich, W, Huber, LA	Dev. Cell	2002
17178906	p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis Teis, D, Taub, N, Kurzbauer, R, Hilber, D, de Araujo, ME, Erlacher, M, Offterdinger, M, Villunger, A, Geley, S, Bohn, G, Klein, C, Hess, MW, Huber, LA	J. Cell Biol.	2006
9733512	MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade Schaeffer, HJ, Catling, AD, Eblen, ST, Collier, LS, Krauss, A, Weber, MJ	Science	1998
15118098	Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists Vomastek, T, Schaeffer, HJ, Tarcsafalvi, A, Smolkin, ME, Bissonette, EA, Weber, MJ	Proc. Natl. Acad. Sci. U.S.A.	2004
21779496	Raf family kinases: old dogs have learned new tricks Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W	Genes Cancer	2011