BRAP autoubiquitinates

Stable Identifier
R-HSA-5674022
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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BRAP autoubiquitinates
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Binding to activated RAS stimulates the ubiquitinase activity of BRAP, promoting autoubiquitination and relieving the inhibition of KSR1 (Methany et al, 2004; Chen et al, 2008; Methany et al, 2009).

Literature References
PubMed ID Title Journal Year
18332145 IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds

Chen, C, Lewis, RE, White, MA

J. Biol. Chem. 2008
14724641 Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

Matheny, SA, Chen, C, Kortum, RL, Razidlo, GL, Lewis, RE, White, MA

Nature 2004
19091743 Signaling threshold regulation by the Ras effector IMP

Matheny, SA, White, MA

J. Biol. Chem. 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of p21 RAS:GTP:BRAP [plasma membrane]
Physical Entity
p21 RAS:GTP:BRAP [plasma membrane]
Activity
ubiquitin protein ligase activity (0061630)
Orthologous Events
BRAP autoubiquitinates (Bos taurus)
BRAP autoubiquitinates (Caenorhabditis elegans)
BRAP autoubiquitinates (Canis familiaris)
BRAP autoubiquitinates (Danio rerio)
BRAP autoubiquitinates (Dictyostelium discoideum)
BRAP autoubiquitinates (Gallus gallus)
BRAP autoubiquitinates (Mus musculus)
BRAP autoubiquitinates (Rattus norvegicus)
BRAP autoubiquitinates (Sus scrofa)
BRAP autoubiquitinates (Xenopus tropicalis)
Authored
Rothfels, K  (2015-02-06)
Reviewed
Roskoski, R Jr  (2015-04-29)
Created
Rothfels, K  (2015-02-10)