Reactome | ub-BRAP [cytosol]

ub-BRAP [cytosol]

Stable Identifier

R-HSA-5674001

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        BRAP autoubiquitinates (Homo sapiens)
        
        p21 RAS:GTP:ub-BRAP [plasma membrane] (Homo sapiens)
        
        ub-BRAP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z569 BRAP

Gene Names

BRAP, RNF52

Chain

chain:1-592

Reference Genes

BioGPS Gene:8315 BRAP

COSMIC (genes):BRAP BRAP

CTD Gene:8315 BRAP

dbSNP Gene:8315 BRAP

ENSEMBL:ENSG00000089234 BRAP

HGNC:1099 BRAP

KEGG Gene (Homo sapiens):8315 BRAP

Monarch:8315 BRAP

NCBI Gene:8315 BRAP

OMIM:604986 BRAP

UCSC:Q7Z569 BRAP

Reference Transcript

RefSeq:NM_006768.4 BRAP

Other Identifiers

0001740195

11724633_at

11751151_a_at

16770256

209922_at

209923_s_at

213473_at

3471701

3471703

3471705

3471706

3471707

3471708

3471709

3471710

3471711

3471712

3471713

3471724

3471726

3471727

3471728

3471729

3471730

3471733

3471734

35500_at

41512_at

63075_s_at

7966427

8315

A_23_P53614

GE54285

GO:0000151

GO:0000165

GO:0003674

GO:0003676

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005829

GO:0006464

GO:0007165

GO:0007265

GO:0008139

GO:0008150

GO:0008270

GO:0009968

GO:0016567

GO:0016740

GO:0031965

GO:0032991

GO:0042802

GO:0043167

GO:0043226

GO:0046872

GO:0061630

Hs.122764.1.S1_3p_s_at

PH_hs_0025720

TC12001974.hg

g3252871_3p_a_at

Participant Of

hasComponent

p21 RAS:GTP:ub-BRAP [plasma membrane]

Other forms of this molecule

BRAP [cytosol]

Inferred To

F6QZK6 [cytosol] (Xenopus tropicalis)

brap [cytosol] (Danio rerio)

brap-2 [cytosol] (Caenorhabditis elegans)

Brap [cytosol] (Mus musculus)

Brap [cytosol] (Rattus norvegicus)

BRAP [cytosol] (Bos taurus)

BRAP [cytosol] (Canis familiaris)

BRAP [cytosol] (Gallus gallus)

BRAP [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_006759.3

OpenTargets

ENSG00000089234

HPA

ENSG00000089234-BRAP

GeneCards

Q7Z569

Ensembl

ENST00000419234, ENSP00000403524, ENSG00000089234

PRO

Q7Z569

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z569 BRAP	2	BRAP [cytosol] (R-HSA-5672938) ub-BRAP [cytosol] (R-HSA-5674001)	0.573	2
UniProt:Q9BW85 YJU2			0.556	3
UniProt:Q5JVL4 EFHC1			0.547	2
UniProt:P01112 HRAS	23	HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912)	0.524	3
UniProt:O75969 AKAP3			0.508	2
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.508	3

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