MAP2Ks phosphorylate MAPKs

Stable Identifier
R-HSA-5672973
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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MAP2Ks phosphorylate MAPKs
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Activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (residues T202 and Y204 in MAPK3, residues T185 and Y187 in MAPK1) (Ray et al, 1988; reviewed in Roskoski, 2012b). MAPK3 and MAPK1 are 84% identical and appear to be stimulated in parallel by all known activators of the MAPK pathway (Lefloch et al, 2009; reviewed in Lloyd, 2006).

Literature References
PubMed ID Title Journal Year
3287375 Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo

Sturgill, TW, Ray, LB

Proc. Natl. Acad. Sci. U.S.A. 1988
16879721 Distinct functions for ERKs?

Lloyd, AC

J. Biol. 2006
22569528 ERK1/2 MAP kinases: structure, function, and regulation

Roskoski, R Jr

Pharmacol. Res. 2012
19242111 Total ERK1/2 activity regulates cell proliferation

Pouysségur, J, Lefloch, R, Lenormand, P

Cell Cycle 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]

Physical Entity
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
This event is regulated
Negatively by
Regulator
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
Active Unit
dual mechanism MAP2K1/2 inhibitors [cytosol]
Regulator
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
Active Unit
single mechanism MAP2K1/2 inhibitors [cytosol]
Regulator
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
Active Unit
dual mechanism MAPK inhibitors [cytosol]
Orthologous Events
MAP2Ks phosphorylate MAPKs (Bos taurus)
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
MAP2Ks phosphorylate MAPKs (Canis familiaris)
MAP2Ks phosphorylate MAPKs (Danio rerio)
MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Mus musculus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Sus scrofa)
MAP2Ks phosphorylate MAPKs (Xenopus tropicalis)
Authored
Rothfels, K  (2014-12-18)
Reviewed
Roskoski, R Jr  (2015-04-28)
Created
Rothfels, K  (2015-02-06)
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