Reactome | MAP2Ks phosphorylate MAPKs

MAP2Ks phosphorylate MAPKs

Stable Identifier

R-HSA-5672973

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

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Activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (residues T202 and Y204 in MAPK3, residues T185 and Y187 in MAPK1) (Ray et al, 1988; reviewed in Roskoski, 2012b). MAPK3 and MAPK1 are 84% identical and appear to be stimulated in parallel by all known activators of the MAPK pathway (Lefloch et al, 2009; reviewed in Lloyd, 2006).

Literature References

PubMed ID	Title	Journal	Year
16879721	Distinct functions for ERKs? Lloyd, AC	J. Biol.	2006
3287375	Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo Ray, LB, Sturgill, TW	Proc. Natl. Acad. Sci. U.S.A.	1988
22569528	ERK1/2 MAP kinases: structure, function, and regulation Roskoski, R Jr	Pharmacol. Res.	2012
19242111	Total ERK1/2 activity regulates cell proliferation Lefloch, R, Pouysségur, J, Lenormand, P	Cell Cycle	2009