Activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (residues T202 and Y204 in MAPK3, residues T185 and Y187 in MAPK1) (Ray et al, 1988; reviewed in Roskoski, 2012b). MAPK3 and MAPK1 are 84% identical and appear to be stimulated in parallel by all known activators of the MAPK pathway (Lefloch et al, 2009; reviewed in Lloyd, 2006).
Sturgill, TW, Ray, LB
Lloyd, AC
Roskoski, R Jr
Pouysségur, J, Lefloch, R, Lenormand, P
protein serine/threonine kinase activity of activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
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