MAP2Ks phosphorylate MAPKs

Stable Identifier
R-HSA-5672973
Type
Reaction
Species
Homo sapiens
Compartment
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Activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (residues T202 and Y204 in MAPK3, residues T185 and Y187 in MAPK1) (Ray et al, 1988; reviewed in Roskoski, 2012b). MAPK3 and MAPK1 are 84% identical and appear to be stimulated in parallel by all known activators of the MAPK pathway (Lefloch et al, 2009; reviewed in Lloyd, 2006).

Literature References
PubMed ID Title Journal Year
3287375 Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo

Sturgill, TW, Ray, LB

Proc. Natl. Acad. Sci. U.S.A. 1988
16879721 Distinct functions for ERKs?

Lloyd, AC

J. Biol. 2006
22569528 ERK1/2 MAP kinases: structure, function, and regulation

Roskoski, R Jr

Pharmacol. Res. 2012
19242111 Total ERK1/2 activity regulates cell proliferation

Pouysségur, J, Lefloch, R, Lenormand, P

Cell Cycle 2009
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]

This event is regulated
Orthologous Events
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