Active mTORC1 binds the ULK1 complex

Stable Identifier
R-HSA-5672817
Type
Reaction [binding]
Species
Homo sapiens
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Under nutrient-rich conditions, the mTORC1 complex associates with the ULK complex (Mizushima 2010). Binding is mediated by Raptor, a substrate recognition subunit of mTORC1, and the PS domain of ULK1 (Hosokawa et al. 2009).

Active mTORC1 phosphorylates ULK1 Ser-758, which disrupts the interaction between ULK1 and AMPK, thereby maintaining ULK1 in an inactive state (Jung et al. 2009, Kim et al. 2011, Egan et al. 2011).

When cellular energy is depleted, AMPK is activated. It inhibits mTORC1 kinase activity via phosphorylation of both TSC2 and raptor (Gwinn et al. 2008). Inhibition of mTORC1 reduces S758 phosphorylation on ULK1 (Shang et al. 2011). The S758-unphosphorylated ULK1 is able to associate with, and be activated by, AMPK.

Literature References
PubMed ID Title Journal Year
19211835 Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

Hosokawa, N, Hara, T, Kaizuka, T, Kishi, C, Takamura, A, Miura, Y, Iemura, S, Natsume, T, Takehana, K, Yamada, N, Guan, JL, Oshiro, N, Mizushima, N

Mol. Biol. Cell 2009
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Orthologous Events
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