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p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
Stable Identifier
R-HSA-5672715
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
Phosphorylation of RAF1 mutants (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
RAF activation (Homo sapiens)
Phosphorylation of RAF (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
Participants
components
'activator' RAFs [cytosol]
(Homo sapiens)
p21 RAS:GTP [plasma membrane]
(Homo sapiens)
YWHAB dimer [cytosol]
(Homo sapiens)
Participates
as a component of
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
Inferred To
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Bos taurus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Caenorhabditis elegans)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Canis familiaris)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Danio rerio)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Dictyostelium discoideum)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Rattus norvegicus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Sus scrofa)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane]
(Xenopus tropicalis)
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