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'activator' RAFs [cytosol]
Stable Identifier
R-HSA-5672709
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Phosphorylation of RAF1 mutants (Homo sapiens)
p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PEBP1 binds activated RAF1 (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Phosphorylation of RAF (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
Participants
members
p-S445,S729-BRAF [cytosol]
(Homo sapiens)
candidates
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol]
(Homo sapiens)
p-S311,Y552 KSR1 [cytosol]
(Homo sapiens)
Participates
as a component of
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
Inferred To
'activator' RAFs [cytosol]
(Bos taurus)
'activator' RAFs [cytosol]
(Caenorhabditis elegans)
'activator' RAFs [cytosol]
(Canis familiaris)
'activator' RAFs [cytosol]
(Danio rerio)
'activator' RAFs [cytosol]
(Dictyostelium discoideum)
'activator' RAFs [cytosol]
(Drosophila melanogaster)
'activator' RAFs [cytosol]
(Gallus gallus)
'activator' RAFs [cytosol]
(Mus musculus)
'activator' RAFs [cytosol]
(Rattus norvegicus)
'activator' RAFs [cytosol]
(Sus scrofa)
'activator' RAFs [cytosol]
(Xenopus tropicalis)
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