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inactive RAFs:YWHAB dimer [cytosol]
Stable Identifier
R-HSA-5672707
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MRAS-complex mutants (Homo sapiens)
Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
inactive RAFs:YWHAB dimer [cytosol] (Homo sapiens)
SHOC2 M1731 mutant abolishes MRAS complex function (Homo sapiens)
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
inactive RAFs:YWHAB dimer [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAF activation (Homo sapiens)
Inactive RAFs bind YWHAB (Homo sapiens)
inactive RAFs:YWHAB dimer [cytosol] (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
inactive RAFs:YWHAB dimer [cytosol] (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
inactive RAFs:YWHAB dimer [cytosol] (Homo sapiens)
Participants
components
inactive RAFs [cytosol]
(Homo sapiens)
YWHAB dimer [cytosol]
(Homo sapiens)
Participates
as an input of
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
as an output of
Inactive RAFs bind YWHAB (Homo sapiens)
Inferred To
inactive RAFs:YWHAB dimer [cytosol]
(Bos taurus)
inactive RAFs:YWHAB dimer [cytosol]
(Caenorhabditis elegans)
inactive RAFs:YWHAB dimer [cytosol]
(Danio rerio)
inactive RAFs:YWHAB dimer [cytosol]
(Drosophila melanogaster)
inactive RAFs:YWHAB dimer [cytosol]
(Gallus gallus)
inactive RAFs:YWHAB dimer [cytosol]
(Mus musculus)
inactive RAFs:YWHAB dimer [cytosol]
(Plasmodium falciparum)
inactive RAFs:YWHAB dimer [cytosol]
(Rattus norvegicus)
inactive RAFs:YWHAB dimer [cytosol]
(Sus scrofa)
inactive RAFs:YWHAB dimer [cytosol]
(Xenopus tropicalis)
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