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MAP2K1:MAPK2K2 heterodimer [cytosol]
Stable Identifier
R-HSA-5672686
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Signaling by BRAF and RAF fusions (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)
MAP2K homo/heterodimers [cytosol] (Homo sapiens)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Homo sapiens)
Participants
components
MAP2K1 [cytosol] (Homo sapiens)
MAP2K2 [cytosol] (Homo sapiens)
Participant Of
hasMember
MAP2K homo/heterodimers [cytosol]
Inferred To
MAP2K1:MAPK2K2 heterodimer [cytosol] (Bos taurus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Caenorhabditis elegans)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Canis familiaris)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Danio rerio)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
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