Reactome | IQGAP1 binds CLIP1 and microtubules

IQGAP1 binds CLIP1 and microtubules

Stable Identifier

R-HSA-5672329

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Once bound to activated RAC1 (RAC1:GTP) or CDC42 (CDC42:GTP), IQGAP1 binds CLIP1 (CLIP-170) via the C-terminus of IQGAP1 and the N-terminus of CLIP1. CLIP1 simultaneously interacts with IQGAP1 and the positive end of microtubules. Formation of the RAC1 or CDC42 complex with IQGAP1, CLIP1 and microtubules determines the orientation of microtubules and results in a polarized cellular morphology (Fukata et al. 2002). The RAC1:GTP:IQGAP1:CLIP1 complex is also involved in the regulation of lamellipodia formation and cell invasion in human breast cancer cells (Suzuki and Takahashi 2008).

Literature References

PubMed ID	Title	Journal	Year
18237546	Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells Takahashi, K, Suzuki, K	Biochem. Biophys. Res. Commun.	2008
12110184	Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 Kaibuchi, K, Kuroda, S, Fukata, M, Noritake, J, Nakagawa, M, Matsuura, Y, Watanabe, T, Yamaga, M, Perez, F, Iwamatsu, A	Cell	2002