Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
IQGAP1 binds the complex of E-cadherin (CDH1), beta-catenin (CTTNB1) and alpha-catenin (CTTNA1) at adherens junctions (Kuroda et al. 1998, Hage et al. 2009) and this interaction is corroborated by menin (MEN1) (Yan et al. 2009). It is implicated that IQGAP1 binding to CTTNB1 causes CTTNA1 to dissociate from the E-cadherin:catenin complex (Kuroda et al. 1998, Fukata et al. 1999). Binding of IQGAP1 to activated RAC1 or CDC42 competes with IQGAP1 association with the CDH1 dimer:CTTNB1:CTTNA1 complex (Kuroda et al. 1998, Fukata et al. 1999, Yan et al. 2009, Hage et al. 2009). Studies done in pancreatic cell lines found that the binding of IQGAP1 to E-cadherin:catenin complex at adherens junctions increases cell adhesion and decreases cell motility (Yan et al. 2009, Hage et al. 2009). On the contrary, studies done in mouse fibroblasts reported that IQGAP1 binding to E-cadherin:catenin complex and the concomitant displacement of CTTNA1 causes dissociation of adherens junctions (Kuroda et al. 1998, Fukata et al. 1999).
Literature References
PubMed ID Title Journal Year
19079338 Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells

Bloom, GS, Yang, Y, Cai, Y, King, C, Kan, HM, Yan, J, Zhang, H, Yuan, CX, Hua, X

Oncogene 2009
10473551 Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin

Itoh, N, Nakagawa, M, Kikuchi, A, Fujisawa, H, Kaibuchi, K, Fukata, M, Kawajiri, A, Kuroda, S, Shoji, I, Matsuura, Y, Yonehara, S

J. Biol. Chem. 1999
19737400 Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells

Giehl, K, Baum, I, Menke, A, Hage, B, Meinel, K

Cell Commun. Signal 2009
9694656 Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

Kaibuchi, K, Ookubo, T, Shoji, I, Fujii, K, Matsuura, Y, Yonehara, S, Nakagawa, M, Fukata, M, Kuroda, S, Izawa, I, Nakamura, T, Nagase, T, Tani, H, Nomura, N

Science 1998
This event is regulated
Orthologous Events
Cite Us!