IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1

Stable Identifier
R-HSA-5672304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IQGAP1 binds the complex of E-cadherin (CDH1), beta-catenin (CTTNB1) and alpha-catenin (CTTNA1) at adherens junctions (Kuroda et al. 1998, Hage et al. 2009) and this interaction is corroborated by menin (MEN1) (Yan et al. 2009). It is implicated that IQGAP1 binding to CTTNB1 causes CTTNA1 to dissociate from the E-cadherin:catenin complex (Kuroda et al. 1998, Fukata et al. 1999). Binding of IQGAP1 to activated RAC1 or CDC42 competes with IQGAP1 association with the CDH1 dimer:CTTNB1:CTTNA1 complex (Kuroda et al. 1998, Fukata et al. 1999, Yan et al. 2009, Hage et al. 2009). Studies done in pancreatic cell lines found that the binding of IQGAP1 to E-cadherin:catenin complex at adherens junctions increases cell adhesion and decreases cell motility (Yan et al. 2009, Hage et al. 2009). On the contrary, studies done in mouse fibroblasts reported that IQGAP1 binding to E-cadherin:catenin complex and the concomitant displacement of CTTNA1 causes dissociation of adherens junctions (Kuroda et al. 1998, Fukata et al. 1999).

Literature References
PubMed ID Title Journal Year
10473551 Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin

Fukata, M, Kuroda, S, Nakagawa, M, Kawajiri, A, Itoh, N, Shoji, I, Matsuura, Y, Yonehara, S, Fujisawa, H, Kikuchi, A, Kaibuchi, K

J. Biol. Chem. 1999
19079338 Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells

Yan, J, Yang, Y, Zhang, H, King, C, Kan, HM, Cai, Y, Yuan, CX, Bloom, GS, Hua, X

Oncogene 2009
19737400 Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells

Hage, B, Meinel, K, Baum, I, Giehl, K, Menke, A

Cell Commun. Signal 2009
9694656 Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

Kuroda, S, Fukata, M, Nakagawa, M, Fujii, K, Nakamura, T, Ookubo, T, Izawa, I, Nagase, T, Nomura, N, Tani, H, Shoji, I, Matsuura, Y, Yonehara, S, Kaibuchi, K

Science 1998
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