KTN1 binds Kinesin-1

Stable Identifier
R-HSA-5672083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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KTN1 binds Kinesin-1
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The C-terminal region of KTN1 (kinectin) binds the cargo-binding tail of the kinesin heavy chain KIF5A and enhances microtubule-stimulated ATPase activity of KIF5A. KIF5A is a part of the conventional kinesin complex, kinesin-1. RHO GTPases, KTN1 and kinesin-1 colocalize on endoplasmic reticulum (ER) membranes and ER-derived vesicles and are thought to be involved in organelle/vesicle motility (Ong et al. 2000, Vignal et al. 2001)
Literature References
PubMed ID Title Journal Year
10913441 Kinectin-kinesin binding domains and their effects on organelle motility

Er, CP, Ong, LL, Kuznetsov, SA, Lim, AP, Yu, H

J. Biol. Chem. 2000
11689693 Kinectin is a key effector of RhoG microtubule-dependent cellular activity

Blangy, A, Gauthier-Rouvière, C, Vignal, E, Martin, M, Fort, P

Mol. Cell. Biol. 2001
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Orthologous Events
KTN1 binds Kinesin-1 (Bos taurus)
KTN1 binds Kinesin-1 (Canis familiaris)
KTN1 binds Kinesin-1 (Mus musculus)
KTN1 binds Kinesin-1 (Rattus norvegicus)
KTN1 binds Kinesin-1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-02-04)
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