KTN1 binds Kinesin-1

Stable Identifier
R-HSA-5672083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The C-terminal region of KTN1 (kinectin) binds the cargo-binding tail of the kinesin heavy chain KIF5A and enhances microtubule-stimulated ATPase activity of KIF5A. KIF5A is a part of the conventional kinesin complex, kinesin-1. RHO GTPases, KTN1 and kinesin-1 colocalize on endoplasmic reticulum (ER) membranes and ER-derived vesicles and are thought to be involved in organelle/vesicle motility (Ong et al. 2000, Vignal et al. 2001)

Literature References
PubMed ID Title Journal Year
11689693 Kinectin is a key effector of RhoG microtubule-dependent cellular activity

Vignal, E, Blangy, A, Martin, M, Gauthier-Rouvière, C, Fort, P

Mol. Cell. Biol. 2001
10913441 Kinectin-kinesin binding domains and their effects on organelle motility

Ong, LL, Lim, AP, Er, CP, Kuznetsov, SA, Yu, H

J. Biol. Chem. 2000
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