ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane

Stable Identifier
Reaction [transition]
Homo sapiens
ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix
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A family of antiport, dimeric ATP-ADP translocases (SLC25A4,5,6), preferentially export ATP from the matrix while importing ADP from the cytosol, thereby maintaining a high ADP:ATP ratio in the matrix. When there are increased energy demands on the body, such as under heavy exercise, cytosolic ADP rises and is exchanged with mitochondrial matrix ATP via the transmembrane ADP:ATP translocase. Increased ADP causes the proton-motive force to be discharged and protons enter via ATPase, thereby regenerating the ATP pool. There are 3 isoforms of translocases in humans with isoform 1 (SLC25A4, NAT1) being the heart/skeletal muscle form.
Literature References
PubMed ID Title Journal Year
24911211 The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels

Zhou, CJ, Newman, LE, Mudigonda, S, Kahn, RA, Mattheyses, AL, Marobbio, CM, Paradies, E

PLoS ONE 2014
11809823 ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter

Sharer, JD, Wallace, DC, Kahn, RA, Van Valkenburgh, H, Shern, JF

Mol. Biol. Cell 2002
Catalyst Activity

adenine transmembrane transporter activity of ARL2:GTP:ARL2BP:SLC25A4 [mitochondrial inner membrane]

Orthologous Events
Cross References
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