Reactome | ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane

ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane

Stable Identifier

R-HSA-5672027

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix

ReviewStatus

5/5

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ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane

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A family of antiport, dimeric ATP-ADP translocases (SLC25A4,5,6), preferentially export ATP from the matrix while importing ADP from the cytosol, thereby maintaining a high ADP:ATP ratio in the matrix. When there are increased energy demands on the body, such as under heavy exercise, cytosolic ADP rises and is exchanged with mitochondrial matrix ATP via the transmembrane ADP:ATP translocase. Increased ADP causes the proton-motive force to be discharged and protons enter via ATPase, thereby regenerating the ATP pool. There are 3 isoforms of translocases in humans with isoform 1 (SLC25A4, NAT1) being the heart/skeletal muscle form.

Literature References

PubMed ID	Title	Journal	Year
24911211	The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels Newman, LE, Zhou, CJ, Mudigonda, S, Mattheyses, AL, Paradies, E, Marobbio, CM, Kahn, RA	PLoS ONE	2014
11809823	ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter Sharer, JD, Shern, JF, Van Valkenburgh, H, Wallace, DC, Kahn, RA	Mol. Biol. Cell	2002